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人类嗜T淋巴细胞病毒1型携带者中,高黏液性肺炎克雷伯菌引起的脓毒性脑膜炎和肝脓肿并发慢性类圆线虫病

Septic Meningitis and Liver Abscess due to Hypermucoviscous Klebsiella pneumoniae Complicated with Chronic Strongyloidiasis in a Human T-lymphotropic Virus 1 Carrier.

作者信息

Hosoda Tomohiro, Sakamoto Mitsuo, Orikasa Hideki, Kubomura Akiko, Misaki Takako, Okabe Nobuhiko

机构信息

Department of Infectious Disease, Kawasaki Municipal Kawasaki Hospital, Japan.

Department of Pathology, Kawasaki Municipal Kawasaki Hospital, Japan.

出版信息

Intern Med. 2020 Jan 1;59(1):129-133. doi: 10.2169/internalmedicine.3403-19. Epub 2019 Aug 21.

Abstract

Recently, severe cases of infection due to hypermucoviscous Klebsiella pneumonia (hmKP) have been reported in Japan. The Amami Islands in Japan are also endemic regions for Strongyloides stercoralis. Disseminated strongyloidiasis strain often causes severe enterobacteria infection; however, whether or not chronic strongyloidiasis induces it remains unclear. We herein report a 71-year-old man who developed meningitis and liver abscess due to hmKP complicated with chronic strongyloidiasis. He died on the seventh hospital day. Strongyloides stercoralis were only found around the polyp in the cecum. Chronic strongyloidiasis can also induce severe infection due to enterobacteria, especially hypervirulent pathogens like hmKP, through the induction of mucosal rupture.

摘要

最近,日本报告了多例由高黏液性肺炎克雷伯菌(hmKP)引起的严重感染病例。日本的奄美群岛也是粪类圆线虫的流行地区。播散性类圆线虫病菌株常导致严重的肠杆菌感染;然而,慢性类圆线虫病是否会引发这种感染仍不清楚。我们在此报告一名71岁男性,他因hmKP合并慢性类圆线虫病而发生脑膜炎和肝脓肿。他在住院第七天死亡。仅在盲肠息肉周围发现了粪类圆线虫。慢性类圆线虫病也可通过诱导黏膜破裂,引发由肠杆菌尤其是像hmKP这样的高毒力病原体导致的严重感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d504/6995716/71a94ceaf2ec/1349-7235-59-0129-g001.jpg

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