高毒力肺炎克雷伯菌：呼吁达成共识定义和国际合作。
Hypervirulent Klebsiella pneumoniae: a Call for Consensus Definition and International Collaboration.
机构信息
Department of Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Department of Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
出版信息
J Clin Microbiol. 2018 Aug 27;56(9). doi: 10.1128/JCM.00959-18. Print 2018 Sep.
Abstract
Hypervirulent strains have higher potential to cause more severe and disseminated infections than classic strains. While initially reported from East Asian countries, cases have now been identified worldwide, sometimes in conjunction with extensive drug resistance. In this issue of the , T. A. Russo et al. (J Clin Microbiol 56:e00776-18, 2018, https://doi.org/10.1128/JCM.00776-18) validated the diagnostic accuracy of biomarkers that differentiate hypervirulent strains from classic strains. This represents a major step forward in building a consensus definition and designing international studies aimed at elucidating the global epidemiology, clinical features, and outcome of this important pathogen.
摘要
高毒力菌株比经典菌株更有可能导致更严重和更广泛的感染。虽然最初报道于东亚国家，但现在已在全球范围内发现了此类病例，有时还伴有广泛的耐药性。在本期的《临床微生物学杂志》中，T. A. 鲁索等人（J Clin Microbiol 56:e00776-18, 2018, https://doi.org/10.1128/JCM.00776-18）验证了区分高毒力和经典菌株的生物标志物的诊断准确性。这是朝着建立共识定义和设计旨在阐明这一重要病原体的全球流行病学、临床特征和结局的国际研究迈出的重要一步。
相似文献
1
Hypervirulent Klebsiella pneumoniae: a Call for Consensus Definition and International Collaboration.高毒力肺炎克雷伯菌：呼吁达成共识定义和国际合作。
J Clin Microbiol. 2018 Aug 27;56(9). doi: 10.1128/JCM.00959-18. Print 2018 Sep.
2
Antimicrobial Resistance of Hypervirulent : Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms.高毒力 耐药性：流行病学、高毒力相关决定因素和耐药机制。
Front Cell Infect Microbiol. 2017 Nov 21;7:483. doi: 10.3389/fcimb.2017.00483. eCollection 2017.
3
Whole genome analysis of hypervirulent Klebsiella pneumoniae isolates from community and hospital acquired bloodstream infection.社区获得性和医院获得性血流感染高毒力肺炎克雷伯菌分离株的全基因组分析。
BMC Microbiol. 2018 Jan 8;18(1):6. doi: 10.1186/s12866-017-1148-6.
4
Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6 years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor.hypervirulent Klebsiella pneumoniae（高粘液型和产菌绿素阳性）在中国老年人中超过 6 年的感染：抗菌药物耐药模式、分子流行病学和危险因素。
Ann Clin Microbiol Antimicrob. 2019 Jan 21;18(1):4. doi: 10.1186/s12941-018-0302-9.
5
Identification of Biomarkers for Differentiation of Hypervirulent Klebsiella pneumoniae from Classical K. pneumoniae.鉴定高毒力肺炎克雷伯菌与经典肺炎克雷伯菌的生物标志物。
J Clin Microbiol. 2018 Aug 27;56(9). doi: 10.1128/JCM.00776-18. Print 2018 Sep.
6
Diversity of virulence level phenotype of hypervirulent Klebsiella pneumoniae from different sequence type lineage.不同序列型系别的高毒力肺炎克雷伯菌毒力表型的多样性。
BMC Microbiol. 2018 Aug 29;18(1):94. doi: 10.1186/s12866-018-1236-2.
7
First two cases of severe multifocal infections caused by Klebsiella pneumoniae in Switzerland: characterization of an atypical non-K1/K2-serotype strain causing liver abscess and endocarditis.瑞士首例由肺炎克雷伯菌引起的严重多发性感染：导致肝脓肿和心内膜炎的非 K1/K2 血清型非典型菌株的特征。
J Glob Antimicrob Resist. 2017 Sep;10:165-170. doi: 10.1016/j.jgar.2017.04.006. Epub 2017 Jul 17.
8
The Galleria mellonella Infection Model Does Not Accurately Differentiate between Hypervirulent and Classical Klebsiella pneumoniae.家蚕感染模型不能准确区分高毒力和经典型肺炎克雷伯菌。
mSphere. 2020 Jan 8;5(1):e00850-19. doi: 10.1128/mSphere.00850-19.
9
Increasing occurrence of antimicrobial-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China.中国出现越来越多的抗微生物药物耐药性超强毒力（高黏液性）肺炎克雷伯菌分离株。
Clin Infect Dis. 2014 Jan;58(2):225-32. doi: 10.1093/cid/cit675. Epub 2013 Oct 7.
10
Evolutionary transition of hypervirulent Klebsiella pneumoniae to multidrug-resistant hypervirulent Klebsiella pneumoniae: Indian experience.高毒力肺炎克雷伯菌向多重耐药高毒力肺炎克雷伯菌的进化转变：印度的经验
Indian J Med Microbiol. 2024 Jul-Aug;50:100619. doi: 10.1016/j.ijmmb.2024.100619. Epub 2024 Jun 12.
引用本文的文献
1
Hypervirulent Carbapenem-resistant Infection: Epidemiology, Virulence, Resistance, and Treatment.高毒力碳青霉烯耐药感染：流行病学、毒力、耐药性及治疗
Infect Drug Resist. 2025 Sep 4;18:4689-4697. doi: 10.2147/IDR.S534490. eCollection 2025.
2
Best Practices in the Development and Use of Experimental Models of Bacterial Pneumonia: An Official American Thoracic Society Workshop Report.细菌性肺炎实验模型开发与应用的最佳实践：美国胸科学会官方研讨会报告
Am J Respir Cell Mol Biol. 2025 Aug;73(2):178-199. doi: 10.1165/rcmb.2025-0322ST.
3
Biofilm Formation, Antibiotic Resistance, and Virulence Analysis of Human and Avian Origin from Jiangsu, China.中国江苏人源和禽源的生物膜形成、抗生素耐药性及毒力分析
Vet Sci. 2025 Jun 30;12(7):628. doi: 10.3390/vetsci12070628.
4
Emergence of ST11-KL64 carbapenem-resistant hypervirulent Klebsiella Pneumoniae isolates harboring bla and iucA from a tertiary teaching hospital in Western China.中国西部一家三级教学医院中携带bla和iucA的ST11-KL64碳青霉烯耐药高毒力肺炎克雷伯菌分离株的出现。
BMC Infect Dis. 2025 Jul 1;25(1):880. doi: 10.1186/s12879-025-11241-6.
5
Hypervirulent : Insights into Virulence, Antibiotic Resistance, and Fight Strategies Against a Superbug.高毒力：对一种超级细菌的毒力、抗生素耐药性及对抗策略的见解
Pharmaceuticals (Basel). 2025 May 15;18(5):724. doi: 10.3390/ph18050724.
6
Virulence characteristics and antibiotic resistance analysis of Klebsiella pneumoniae isolated from pig farms in Xinjiang, China: revealing potential zoonotic risks.中国新疆猪场分离的肺炎克雷伯菌的毒力特征及抗生素耐药性分析：揭示潜在的人畜共患病风险
Porcine Health Manag. 2025 May 7;11(1):25. doi: 10.1186/s40813-025-00424-x.
7
New insights and perspectives on the virulence of hypervirulent Klebsiella pneumoniae.关于高毒力肺炎克雷伯菌毒力的新见解和观点。
Folia Microbiol (Praha). 2025 Apr 8. doi: 10.1007/s12223-025-01261-9.
8
Major Predominant Serotypes and Virulence Genes and Antibiotic Resistance Characteristics of Clinical Isolates in Middle and East China.中国中东部地区临床分离株的主要优势血清型、毒力基因及抗生素耐药特征
Infect Drug Resist. 2025 Mar 13;18:1451-1464. doi: 10.2147/IDR.S502323. eCollection 2025.
9
Influence of the polysaccharide capsule on virulence and fitness of .多糖荚膜对……的毒力和适应性的影响
Front Microbiol. 2025 Feb 6;16:1450984. doi: 10.3389/fmicb.2025.1450984. eCollection 2025.
10
Hypervirulent (hv): Overview, Epidemiology, and Laboratory Detection.高毒力（hv）：概述、流行病学及实验室检测
Pathog Immun. 2025 Jan 24;10(1):80-119. doi: 10.20411/pai.v10i1.777. eCollection 2024.
本文引用的文献
1
Identification of Biomarkers for Differentiation of Hypervirulent Klebsiella pneumoniae from Classical K. pneumoniae.鉴定高毒力肺炎克雷伯菌与经典肺炎克雷伯菌的生物标志物。
J Clin Microbiol. 2018 Aug 27;56(9). doi: 10.1128/JCM.00776-18. Print 2018 Sep.
2
Molecular epidemiology of Klebsiella pneumoniae K1 and K2 isolates in Japan.日本肺炎克雷伯菌K1和K2分离株的分子流行病学
Diagn Microbiol Infect Dis. 2018 Aug;91(4):354-359. doi: 10.1016/j.diagmicrobio.2018.03.010. Epub 2018 Mar 20.
3
A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study.中国医院中致命的 ST11 碳青霉烯类耐药超毒力肺炎克雷伯菌爆发：一项分子流行病学研究。
Lancet Infect Dis. 2018 Jan;18(1):37-46. doi: 10.1016/S1473-3099(17)30489-9. Epub 2017 Aug 29.
4
Convergence of carbapenem-resistance and hypervirulence in Klebsiella pneumoniae.肺炎克雷伯菌中碳青霉烯耐药性与高毒力的趋同。
Lancet Infect Dis. 2018 Jan;18(1):2-3. doi: 10.1016/S1473-3099(17)30517-0. Epub 2017 Aug 29.
5
Metabolite Transporter PEG344 Is Required for Full Virulence of Hypervirulent Klebsiella pneumoniae Strain hvKP1 after Pulmonary but Not Subcutaneous Challenge.代谢物转运蛋白PEG344是高毒力肺炎克雷伯菌菌株hvKP1肺部感染而非皮下感染后实现完全毒力所必需的。
Infect Immun. 2017 Sep 20;85(10). doi: 10.1128/IAI.00093-17. Print 2017 Oct.
6
High Prevalence of Hypervirulent Klebsiella pneumoniae Infection in China: Geographic Distribution, Clinical Characteristics, and Antimicrobial Resistance.中国高毒力肺炎克雷伯菌感染的高流行率：地理分布、临床特征及抗菌药物耐药性
Antimicrob Agents Chemother. 2016 Sep 23;60(10):6115-20. doi: 10.1128/AAC.01127-16. Print 2016 Oct.
7
Primary osteomyelitis caused by hypervirulent Klebsiella pneumoniae.由高毒力肺炎克雷伯菌引起的原发性骨髓炎。
Lancet Infect Dis. 2016 Sep;16(9):e190-e195. doi: 10.1016/S1473-3099(16)30021-4. Epub 2016 Jul 9.
8
Emergence of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae Strains in China.中国碳青霉烯类耐药血清型K1高毒力肺炎克雷伯菌菌株的出现。
Antimicrob Agents Chemother. 2015 Nov 16;60(1):709-11. doi: 10.1128/AAC.02173-15. Print 2016 Jan.
9
First report of two rapid-onset fatal infections caused by a newly emerging hypervirulent K. Pneumonia ST86 strain of serotype K2 in China.中国首次报告两例由新出现的高毒力肺炎克雷伯菌血清型K2 ST86菌株引起的快速致死性感染。
Front Microbiol. 2015 Jul 21;6:721. doi: 10.3389/fmicb.2015.00721. eCollection 2015.
10
Mapping the Evolution of Hypervirulent Klebsiella pneumoniae.绘制高毒力肺炎克雷伯菌的进化图谱。
mBio. 2015 Jul 21;6(4):e00630. doi: 10.1128/mBio.00630-15.
Zotero 插件