Veisani Yousef, Jenabi Ensiyeh, Delpisheh Ali, Khazaei Salman
Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Pediatric Developmental Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Int J Reprod Biomed. 2019 Mar 3;17(1):1-10. doi: 10.18502/ijrm.v17i1.3815. eCollection 2019 Jan.
The etiological nature of preeclampsia is heterogeneous. The use of biomarkers indices in early pregnancy helps to have appropriate stratification of pregnancies into high- and low risk for the purpose of choosing timely interventions.
The aim of this systematic review was to determine the pathogenic role of soluble soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) in the prediction of preeclampsia in women.
We performed a systematic search of the international databases including PubMed, Scopus, and Web of Science until August 2017. The quality of included studies was assessed using the Newcastle-Ottawa Scale. The primary outcome in this review was preeclampsia. The statistical heterogeneity was assessed using the X test and quantified by I . Pooled effects size was obtained by random effects model. Subgroup analyses were also carried out.
Totally, 284 records were identified in the initial search and 15 records were finally included in the meta-analysis. The pooled odds ratios (ORs) for the association between the high level of sFlt-1 and low level of PlGF and subsequent development of preeclampsia among women were 5.20 (95% CI: 1.24-9.16) and 2.53 (95% CI: 1.33-3.75), respectively. The mean difference for sFlt-1 and PlGF in women with preeclampsia compared to controls was 1.15 (95% CI: 0.43-1.86) and -0.94 (95% CI: -1.37-0.52), respectively.
According to the results from this meta-analysis, increased levels of sFlt-1 and reduced levels of PlGF predict the subsequent development of preeclampsia.
子痫前期的病因性质是异质性的。在妊娠早期使用生物标志物指标有助于将妊娠适当地分层为高风险和低风险，以便选择及时的干预措施。
本系统评价的目的是确定可溶性fms样酪氨酸激酶-1（sFlt-1）和胎盘生长因子（PlGF）在预测女性子痫前期中的致病作用。
我们对包括PubMed、Scopus和Web of Science在内的国际数据库进行了系统检索，直至2017年8月。使用纽卡斯尔-渥太华量表评估纳入研究的质量。本评价的主要结局是子痫前期。使用X检验评估统计异质性，并通过I进行量化。采用随机效应模型获得合并效应量。还进行了亚组分析。
在初始检索中总共识别出284条记录，最终15条记录纳入荟萃分析。sFlt-1水平高和PlGF水平低与女性随后发生子痫前期之间关联的合并比值比（OR）分别为5.20（95%CI：1.24-9.16）和2.53（95%CI：1.33-3.75）。与对照组相比，子痫前期女性中sFlt-1和PlGF的平均差异分别为1.15（95%CI：0.43-1.86）和-0.94（95%CI：-1.37-0.52）。
根据该荟萃分析的结果，sFlt-1水平升高和PlGF水平降低可预测子痫前期的后续发生。
