中国某三级医疗中心妊娠期急性脂肪肝：一项回顾性研究。
Acute fatty liver of pregnancy in a Chinese Tertiary Care Center: a retrospective study.
机构信息
Department of Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
出版信息
Arch Gynecol Obstet. 2019 Oct;300(4):897-901. doi: 10.1007/s00404-019-05259-w. Epub 2019 Aug 21.
PURPOSE
To describe some prenatal clinical features and laboratory findings of AFLP and provide the clinicians with potential predictors in postpartum recovery time.
METHODS
Forty-four cases of AFLP previously treated in the First Affiliated Hospital of Zhengzhou University were retrospectively reviewed.
RESULTS
The maternal and fetal mortalities after treatment were both 18.2%. The main symptoms of AFLP were nausea and vomiting (63.6%), jaundice (61.4%). Moreover, the most common maternal complication was acute renal dysfunction (79.5%), followed by DIC (47.7%) and MODS (38.6%). The level of platelets, total protein and total bilirubin were found to be correlated with postpartum recovery time (Pearson correlation coefficient 0.434, P = 0.008; 0.466, P = 0.005; 0.484, P = 0.003).
CONCLUSIONS
AFLP is a rare, but lethal complication in the third trimester. Termination of pregnancy should be applied once AFLP was highly suspected. Prenatal platelets, total protein and total bilirubin may be potential predictors of postpartum recovery.
目的
描述 AFLP 的一些产前临床特征和实验室结果，并为临床医生提供产后恢复时间的潜在预测指标。
方法
回顾性分析郑州大学第一附属医院此前治疗的 44 例 AFLP 病例。
结果
治疗后的母婴死亡率均为 18.2%。AFLP 的主要症状为恶心和呕吐（63.6%）、黄疸（61.4%）。此外，最常见的产妇并发症是急性肾功能障碍（79.5%），其次是 DIC（47.7%）和 MODS（38.6%）。血小板、总蛋白和总胆红素水平与产后恢复时间相关（Pearson 相关系数 0.434，P=0.008；0.466，P=0.005；0.484，P=0.003）。
结论
AFLP 是妊娠晚期罕见但致命的并发症。一旦高度怀疑 AFLP，应终止妊娠。产前血小板、总蛋白和总胆红素可能是产后恢复的潜在预测指标。
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