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细胞内运输在高尔基体带的中心粒依赖性形成中的作用。

Role of Intracellular Transport in the Centriole-Dependent Formation of Golgi Ribbon.

作者信息

Mironov Alexander A, Dimov Ivan D, Beznoussenko Galina V

机构信息

The FIRC Institute of Molecular Oncology, Milan, Italy.

Department of Anatomy, Saint Petersburg State Paediatric Medical University, Saint Petersburg, Russia.

出版信息

Results Probl Cell Differ. 2019;67:49-79. doi: 10.1007/978-3-030-23173-6_4.

Abstract

The intracellular transport is the most confusing issue in the field of cell biology. The Golgi complex (GC) is the central station along the secretory pathway. It contains Golgi glycosylation enzymes, which are responsible for protein and lipid glycosylation, and in many cells, it is organized into a ribbon. Position and structure of the GC depend on the position and function of the centriole. Here, we analyze published data related to the role of centriole and intracellular transport (ICT) for the formation of Golgi ribbon and specifically stress the importance of the delivery of membranes containing cargo and membrane proteins to the cell centre where centriole/centrosome is localized. Additionally, we re-examined the formation of Golgi ribbon from the point of view of different models of ICT.

摘要

细胞内运输是细胞生物学领域中最令人困惑的问题。高尔基体复合体(GC)是分泌途径中的中心枢纽。它含有高尔基体糖基化酶,负责蛋白质和脂质的糖基化,并且在许多细胞中,它被组织成一条带状结构。GC的位置和结构取决于中心粒的位置和功能。在这里,我们分析了与中心粒和细胞内运输(ICT)在高尔基体带状结构形成中的作用相关的已发表数据,并特别强调了将含有货物和膜蛋白的膜递送到中心粒/中心体所在的细胞中心的重要性。此外,我们从不同的ICT模型角度重新审视了高尔基体带状结构的形成。

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