Division of Nutrition and Metabolism Research, Korea Food Research Institute, Wanju-gun, Jeollabuk-do, Republic of Korea.
Food Biotechnology Program, Korea University of Science and Technology, Daejeon, Republic of Korea.
J Sci Food Agric. 2019 Dec;99(15):7008-7015. doi: 10.1002/jsfa.9993. Epub 2019 Oct 8.
Silkworm droppings have long been used in traditional medicine to remedy allergic itching, palsy, blood circulation problems, and arthritis in Asian countries. To investigate the anti-allergic effect of silkworm dropping extract (SDE) and its mechanism, we used a mouse model of food allergy induced by ovalbumin (OVA).
SDE ameliorated the symptoms of OVA-induced food allergies, and the levels of T helper 2 (Th2)-related cytokines [such as interleukin (IL)-4, IL-5, IL-10, and IL-13] were found to be significantly decreased in both the spleen and mesenteric lymph nodes by SDE. Furthermore, SDE treatment directly inhibited OVA permeation, IL-4 production, and degranulation of mast cells; in contrast, immunoglobulin E (IgE) production from B cells was not affected.
These results suggest that SDE has potential anti-allergic activities, and SDE may be useful in the treatment/prevention of allergic disorders such as food allergies, serving as therapeutic agents. © 2019 Society of Chemical Industry.
在亚洲国家，蚕沙在传统医学中一直被用于治疗过敏瘙痒、瘫痪、血液循环问题和关节炎。为了研究蚕沙提取物（SDE）的抗过敏作用及其机制，我们使用卵清蛋白（OVA）诱导的食物过敏小鼠模型进行了研究。
SDE 改善了 OVA 诱导的食物过敏症状，并且 SDE 使脾脏和肠系膜淋巴结中的 T 辅助 2（Th2）相关细胞因子（如白细胞介素（IL）-4、IL-5、IL-10 和 IL-13）水平显著降低。此外，SDE 处理直接抑制了 OVA 的渗透、IL-4 的产生和肥大细胞的脱颗粒，而 B 细胞的免疫球蛋白 E（IgE）产生不受影响。
这些结果表明 SDE 具有潜在的抗过敏活性，SDE 可能可用于治疗/预防食物过敏等过敏疾病，作为治疗药物。© 2019 化学工业协会。
