Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castellón, Castelló de la Plana, Spain.
Departamento de Metodología de las Ciencias del Comportamiento, Universitat de València, València, València, Spain.
Addict Biol. 2020 Jul;25(4):e12820. doi: 10.1111/adb.12820. Epub 2019 Aug 22.
Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The aim of this study was to investigate how cocaine addiction affected the left frontoparietal network during goal-directed behavior in a stop-signal task (SST) with reward contingencies by correct task performance. Twenty-eight healthy controls (HC) and 30 abstinent cocaine-dependent patients (ACD) performed SST with monetary reward contingencies while undergoing a functional magnetic resonance imaging scan. The results showed that the left frontoparietal network (FPN) displayed an effect of cocaine addiction depending on reward contingencies rather than inhibition accuracy; and, second, we observed a negative correlation between dependence severity and the modulation of the left FPN network by the monetary reward in ACD. These findings highlight the role of the left FPN in the motivational effects of cocaine dependence.
可卡因成瘾的特征是参与目标导向行为的动机和认知过程发生改变。最近的研究表明，成瘾行为可归因于大功能网络活性的改变。本研究旨在通过正确的任务表现，在具有奖励条件的停止信号任务（SST）中，探究可卡因成瘾如何影响左额顶网络在目标导向行为中的作用。二十八名健康对照者（HC）和三十名戒断的可卡因依赖患者（ACD）在进行功能磁共振成像扫描的同时，完成具有货币奖励条件的 SST。结果表明，左额顶网络（FPN）显示出可卡因成瘾的影响，这取决于奖励条件，而不是抑制准确性；其次，我们观察到在 ACD 中，依赖严重程度与货币奖励对左 FPN 网络的调节之间存在负相关。这些发现强调了左 FPN 在可卡因依赖动机效应中的作用。
