From the Department of Neuroradiology, Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munich, Germany (Gürsel, Bremer, Schmitz-Koep, Avram, Koch); the TUM-Neuroimaging Center (TUM-NIC), Technical University of Munich, Einsteinstr. 1, 81675 Munich, Germany (Gürsel, Avram); the Department of Psychology, Ludwig-Maximilians-Universität München, Munich, 80802, Germany (Reinholz); and the Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Feodor-Lynen Straße 17, 81377, Munich, Germany (Franzmeier).
J Psychiatry Neurosci. 2020 May 1;45(3):214-221. doi: 10.1503/jpn.190038.
Resting-state functional MRI (fMRI) studies commonly report alterations in 3 core networks in obsessive–compulsive disorder (OCD) — the frontoparietal network, the default mode network and the salience network — defined by functionally connected infraslow oscillations in ongoing brain activity. However, most of these studies observed static functional connectivity in the brains of patients with OCD.
To investigate dynamic functional connectivity alterations and widen the evidence base toward the triple network model in OCD, we performed group-based independent component and sliding time window analyses in 49 patients with OCD and 41 healthy controls.
The traditional independent component analysis showed alterations in the left frontoparietal network as well as between the left and right frontoparietal networks in patients with OCD compared with healthy controls. For dynamic functional connectivity, the sliding time window approach revealed peak dysconnectivity between the left and right frontoparietal networks and between the left frontoparietal network and the salience network.
The number of independent components, noise in the resting-state fMRI images, the heterogeneity of the OCD sample, and comorbidities and medication status in the patients could have biased the results.
Disrupted modulation of these intrinsic brain networks may contribute to the pathophysiology of OCD.
静息态功能磁共振成像（fMRI）研究常报道强迫症（OCD）中 3 个核心网络的改变——额顶网络、默认模式网络和突显网络——由脑活动中功能连接的亚慢振荡定义。然而，这些研究中的大多数观察到 OCD 患者大脑中的静态功能连接。
为了研究动态功能连接的改变，并为 OCD 的三重网络模型提供更广泛的证据基础，我们对 49 名 OCD 患者和 41 名健康对照者进行了基于组的独立成分和滑动时间窗口分析。
传统的独立成分分析显示，与健康对照组相比，OCD 患者的左侧额顶网络以及左右额顶网络之间存在改变。对于动态功能连接，滑动时间窗口方法显示左、右额顶网络之间以及左额顶网络和突显网络之间存在峰值去连接。
独立成分的数量、静息态 fMRI 图像中的噪声、OCD 样本的异质性以及患者的合并症和用药情况可能会影响结果。
这些内在脑网络的调节障碍可能有助于 OCD 的病理生理学。
