基于喜树碱衍生物和水溶性柱[5]芳烃构建的双功能超分子前药囊泡用于癌症诊断和治疗。

Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy.

机构信息

Key Laboratory of Mesoscopic Chemistry of MOE, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.

出版信息

Chem Commun (Camb). 2019 Sep 10;55(73):10892-10895. doi: 10.1039/c9cc05859a.

DOI:10.1039/c9cc05859a

PMID:31436766

Abstract

Bifunctional supramolecular prodrug vesicles have been successfully constructed based on the complexation between a glutathione (GSH)-responsive prodrug guest molecule (DNS-CPT) and a water-soluble pillar[5]arene (WP5) for cancer diagnosis and therapy. Under the microenvironment of cancer cells with high GSH concentration, 7-ethyl-10-hydroxycamptothecin (SN-38) with strong yellow fluorescence can be efficiently released from the prodrug DNS-CPT for drug location and cancer therapy.

摘要

基于谷胱甘肽（GSH）响应前药客体分子（DNS-CPT）与水溶性柱芳烃（WP5）之间的络合作用，成功构建了双功能超分子前药囊泡，用于癌症诊断和治疗。在具有高 GSH 浓度的癌细胞的微环境下，具有强黄色荧光的 7-乙基-10-羟基喜树碱（SN-38）可以从前药 DNS-CPT 中高效释放，用于药物定位和癌症治疗。