Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.
Chem Commun (Camb). 2018 Jul 19;54(59):8198-8201. doi: 10.1039/c8cc04334e.
Based on the host-guest interaction between a CPT-conjugated prodrug amphiphile (CPT-ss-Py) and a water-soluble pillar[5]arene (P5), a GSH-responsive supramolecular chemotherapeutic drug (P5⊃CPT-ss-Py) was fabricated. Through this supramolecular formulation, internalization and anticancer efficacy were greatly increased.
基于 CPT 偶联前药两亲体（CPT-ss-Py）与水溶性杯[5]芳烃（P5）之间的主客体相互作用，构建了一种 GSH 响应性超分子化疗药物（P5⊃CPT-ss-Py）。通过这种超分子制剂，显著提高了内化和抗癌效果。
