Andes W A
Section of Hematology/Medical Oncology, Tulane University, School of Medicine, New Orleans, LA 70112.
Invest Radiol. 1988 Nov;23 Suppl 2:S346-50. doi: 10.1097/00004424-198811002-00007.
Factor VIII and fibrinogen play an important role in hemostasis and thrombosis because they help bridge functions between platelets, endothelial cells, and the soluble coagulation system. In the present study, we found that the various contrast media examined in concentrations adequate to cause marked anticoagulation did not markedly affect either factor VIII or fibrinogen. These media act predominantly as inhibitors of other fibrinogen functions, not as protein denaturation agents.
凝血因子 VIII 和纤维蛋白原在止血和血栓形成中发挥着重要作用，因为它们有助于在血小板、内皮细胞和可溶性凝血系统之间建立起功能联系。在本研究中，我们发现，所检测的各种造影剂在足以引起显著抗凝作用的浓度下，对凝血因子 VIII 或纤维蛋白原均无明显影响。这些造影剂主要作为其他纤维蛋白原功能的抑制剂，而非蛋白质变性剂。
