Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran.
Fetal Pediatr Pathol. 2020 Aug;39(4):334-345. doi: 10.1080/15513815.2019.1652378. Epub 2019 Aug 22.
We performed a meta-analysis to clarify the association of endothelial nitric oxide synthase (eNOS) and angiotensin I-converting enzyme (ACE) gene polymorphisms with retinopathy of prematurity (ROP) risk. PubMed, Medline, and Embase literatures up to June 01, 2019, were reviewed. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of associations. Eighteen case-control studies including 14 studies (810 cases and 1754 controls) on eNOS polymorphisms and four studies (1014 cases and 1215 controls) on ACE I/D polymorphism were selected. Overall, analysis showed that infants with the ACE I/D polymorphism have an increased susceptibility to ROP. No association of eNOS 27-bp, 894 G > T and -786 T > C polymorphisms with ROP risk was found. ACE I/D polymorphism may serve as genetic biomarker of increased ROP risk. The eNOS polymorphisms do not appear to influence susceptibility to ROP.
我们进行了荟萃分析，以阐明内皮型一氧化氮合酶 (eNOS) 和血管紧张素 I 转换酶 (ACE) 基因多态性与早产儿视网膜病变 (ROP) 风险的关联。检索了截至 2019 年 6 月 1 日的 PubMed、Medline 和 Embase 文献。使用比值比 (OR) 和 95%置信区间 (CI) 来估计关联的强度。选择了 18 项病例对照研究，其中包括 14 项关于 eNOS 多态性的研究（810 例病例和 1754 例对照）和 4 项关于 ACE I/D 多态性的研究（1014 例病例和 1215 例对照）。总体分析表明，ACE I/D 多态性的婴儿患 ROP 的易感性增加。eNOS 27-bp、894G>T 和 -786T>C 多态性与 ROP 风险无关联。ACE I/D 多态性可能是 ROP 风险增加的遗传生物标志物。eNOS 多态性似乎不影响 ROP 的易感性。
