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IL-12B rs3212227 和 IL-6 rs1800795 多态性与宫颈癌易感性的关联：系统评价和荟萃分析。

Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis.

机构信息

Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran.

Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Asian Pac J Cancer Prev. 2020 May 1;21(5):1197-1206. doi: 10.31557/APJCP.2020.21.5.1197.

DOI:10.31557/APJCP.2020.21.5.1197
PMID:32458622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7541893/
Abstract

BACKGROUND

Primary studies have shown that the IL-12B rs3212227 and IL-6 rs1800795 polymorphisms are associated with an increased risk of cervical cancer. However, conflicting results warrant a meta-analysis to obtain more precise estimates.

METHODS

A comprehensive literate search on PubMed, Web of Science, Scopus, CNKI, and SciELO was performed to collect all eligible studies up to November 10, 2019. The pooled odds ratios (OR) and 95% confidence intervals (CI) were used to calculate the risk. This meta-analysis was carried out by utilizing CMA software.

RESULTS

A total of eleven case-control studies including four studies on IL-12B rs3212227 and seven studies on IL-6 rs1800795 were selected. Pooled ORs revealed that the IL-6 rs1800795 polymorphism was significantly associated with an increased risk of cervical cancer (C vs. G: OR = 1.294, 95% CI 1.071-1.564, p= 0.007; CC vs. GG: OR = 1.633, 95% CI 1.059-2.520, p= 0.027; CC+CG vs. GG: OR = 1.312, 95% CI 1.048-1.643, p= 0.018; and CC vs. CG+GG: OR = 1.592, 95% CI 1.268-1.999, p≤0.001), but not IL-12B rs3212227 polymorphism. Stratified analysis by ethnicity revealed that both IL-12B rs3212227 and IL-6 rs1800795 polymorphisms were associated with risk of cervical cancer in Asian women.

CONCLUSIONS

Our pooled data revealed that the IL-12B rs3212227 and IL-6 rs1800795 polymorphisms may be used to identify individuals at high risk of cervical cancer in Asian women.
.

摘要

背景

初步研究表明，IL-12B rs3212227 和 IL-6 rs1800795 多态性与宫颈癌风险增加相关。然而，相互矛盾的结果需要进行荟萃分析以获得更准确的估计。

方法

我们在 PubMed、Web of Science、Scopus、CNKI 和 SciELO 上进行了全面的文献检索，以收集截至 2019 年 11 月 10 日的所有合格研究。使用合并的优势比（OR）和 95%置信区间（CI）来计算风险。该荟萃分析使用 CMA 软件进行。

结果

共纳入了 11 项病例对照研究，其中包括 4 项关于 IL-12B rs3212227 的研究和 7 项关于 IL-6 rs1800795 的研究。合并的 OR 表明，IL-6 rs1800795 多态性与宫颈癌风险增加显著相关（C 与 G：OR = 1.294，95%CI 1.071-1.564，p=0.007；CC 与 GG：OR = 1.633，95%CI 1.059-2.520，p=0.027；CC+CG 与 GG：OR = 1.312，95%CI 1.048-1.643，p=0.018；CC 与 CG+GG：OR = 1.592，95%CI 1.268-1.999，p≤0.001），而 IL-12B rs3212227 多态性则不然。按种族进行分层分析表明，IL-12B rs3212227 和 IL-6 rs1800795 多态性均与亚洲女性宫颈癌风险相关。

结论

我们的汇总数据表明，IL-12B rs3212227 和 IL-6 rs1800795 多态性可用于识别亚洲女性宫颈癌高危个体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b5/7541893/a2c32536af3b/APJCP-21-1197-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b5/7541893/7877b2c33043/APJCP-21-1197-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b5/7541893/b899914aa7e7/APJCP-21-1197-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b5/7541893/a2c32536af3b/APJCP-21-1197-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b5/7541893/7877b2c33043/APJCP-21-1197-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b5/7541893/b899914aa7e7/APJCP-21-1197-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93b5/7541893/a2c32536af3b/APJCP-21-1197-g003.jpg

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