Cazals Y, Li X Q, Aurousseau C, Didier A
Laboratoire d'Audiologie expérimentale, INSERM unité 229, Université Bordeaux II, France.
Hear Res. 1988 Oct;36(1):89-96. doi: 10.1016/0378-5955(88)90139-6.
Aspirin is known to be ototoxic when administered at high doses. Its mode of action is unknown but an alteration of the vascular function has been suspected. To further document this hypothesis, acute effects of some vasoactive agents on the ototoxicity of aspirin were tested in experiments on the guinea pig using sensori-neural electrophysiological responses and morphometry of the vessels of the stria and the spiral lamina. Electrophysiological measures showed no modification of sensory responses but neural responses revealed clear changes after administration of noradrenalin related agents, limited modifications after a drug acting partly as a serotonin antagonist, and no change after a dopaminergic agent. Morphometric studies showed no modification of the strial but some effect on the spiral vessels. The results are compatible with the hypothesis of a vascular involvement in the ototoxicity of aspirin and they point toward an interaction with the noradrenergic sympathetic cochlear system in the spiral lamina.
已知大剂量使用阿司匹林时具有耳毒性。其作用方式尚不清楚，但怀疑与血管功能改变有关。为进一步证实这一假设，在豚鼠实验中，利用感觉神经电生理反应以及血管纹和螺旋板血管的形态测量法，测试了一些血管活性药物对阿司匹林耳毒性的急性影响。电生理测量结果显示感觉反应无变化，但神经反应显示，给予去甲肾上腺素相关药物后有明显变化，给予部分作用为血清素拮抗剂的药物后有有限变化，给予多巴胺能药物后无变化。形态测量研究显示血管纹无变化，但对螺旋血管有一些影响。这些结果与阿司匹林耳毒性涉及血管的假设相符，并表明其与螺旋板中去甲肾上腺素能交感耳蜗系统存在相互作用。
