Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Neuron. 2019 Aug 21;103(4):547-549. doi: 10.1016/j.neuron.2019.07.031.
Parkinson's disease is a neurodegenerative movement disorder; however, peripheral symptoms can arise decades prior. In this issue of Neuron, Kim et al. (2019) provide evidence that progressive α-synuclein aggregation initiating in the gut could be a pathogenic epicenter anatomically rippling throughout the nervous system.
帕金森病是一种神经退行性运动障碍；然而，外周症状可能在几十年前就出现了。在本期《神经元》杂志上，Kim 等人（2019）提供了证据，表明从肠道开始的渐进性α-突触核蛋白聚集可能是一种具有致病性的解剖学起源中心，在整个神经系统中呈涟漪状扩散。
