Clinical Neurophysiology and Fundación de Investigación La Princesa, Hospital Universitario La Princesa, Madrid, Spain.
Clinical Neurophysiology and Fundación de Investigación La Princesa, Hospital Universitario La Princesa, Madrid, Spain.
Clin Neurophysiol. 2019 Oct;130(10):1926-1936. doi: 10.1016/j.clinph.2019.07.026. Epub 2019 Aug 8.
During deep brain stimulation (DBS) surgery, we analysed somatosensory evoked potentials (SSEPs) using microelectrode recordings (MERs) in patients under general anaesthesia.
We obtained MERs from 5 patients with refractory epilepsy. Off-line analysis isolated local field potentials (LFPs, 2-200 Hz) and high frequency components (HFCs, 0.5-5 kHz). Trajectories were reconstructed off-line.
The ventral caudate (V.c.) nucleus was most frequently recorded from (171 mm). Very high frequency oscillations (VHFOs) were recorded up to 8 mm in length from all 4 electrodes but were most frequently recorded from the V.c. The properties of VHFOs were similar among all nuclei (frequency >1500 Hz, amplitude ∼3 µV, starting time ∼14 ms, duration 8-9 ms). Consecutive recordings did not show any synchronization or propagation, but a new kind of potential (high frequency oscillation, HFO) appeared abruptly inside the V.c. (frequency = 848 ± 66 Hz, amplitude = 5.2 ± 1.8 µV starting at 17.7 ± 0.5 ms, spanning 3.4 ± 0.3 ms).
VHFOs are widely extending and cannot be ascribed to the V.c. HFOs in patients under general anaesthesia can serve as a landmark to identify the V.c. in thalamic DBS surgery.
Thalamic processing involves nuclei other than the V.c, and HFO can be used to improve DBS surgery.
在全麻下进行脑深部刺激（DBS）手术时，我们使用微电极记录（MER）分析感觉诱发电位（SSEP）。
我们从 5 例难治性癫痫患者中获得了 MER。离线分析分离局部场电位（LFPs，2-200Hz）和高频成分（HFCs，0.5-5kHz）。轨迹离线重建。
腹侧尾状核（V.c.）核是最常被记录的部位（171mm）。所有 4 个电极均记录到长度达 8mm 的超高频率振荡（VHFO），但 V.c.记录到的频率最高。VHFOs 的特性在所有核中均相似（频率>1500Hz，幅度约为 3µV，起始时间约为 14ms，持续时间为 8-9ms）。连续记录未显示任何同步或传播，但在 V.c.内突然出现一种新的电位（高频振荡，HFO）（频率=848±66Hz，幅度=5.2±1.8µV，起始时间为 17.7±0.5ms，跨度为 3.4±0.3ms）。
VHFOs 广泛延伸，不能归因于 V.c.全麻患者的 HFOs可作为识别丘脑 DBS 手术中 V.c.的标志物。
丘脑处理涉及除 V.c.以外的核，HFO 可用于改善 DBS 手术。
