Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials, College of Physics, Chongqing University, Chongqing, 401331, People's Republic of China.
Nanotechnology. 2019 Nov 22;30(47):475202. doi: 10.1088/1361-6528/ab3dc1. Epub 2019 Aug 22.
Surface enhanced Raman spectroscopy (SERS) detection in microfluidics is an interesting topic for its high sensitivity, miniaturization and online detection. In this work, a SERS detection in microfluidics with the help of the Ag nanowire aggregating based on dielectrophoresis (DEP) is reported. The Raman intensities of molecule in microfluidics is greatly enhanced in the naturally generated nanogaps of Ag nanowire aggregating modulated by DEP. Firstly, the influence of DEP voltage and time on Ag nanowire aggregating is investigated to figure out the optimal condition for SERS. And then, the SERS intensities of methylene blue and rhodamine6G at various concentration with high reproducibility and uniformity are studied. Furthermore, the experiment data demonstrate this DEP-SERS system could be repeated used for different molecule detections. At last, the SERS of melamine is measured to explore its application on food safety. Our work anticipates this nanowire assisted repeatable DEP-SERS detection in microfluidics with high sensitivity could meet the emerging needs in environmental pollution monitoring, food safety evaluation, and so on.
基于电介质电泳（DEP）的银纳米线聚集的微流控中的表面增强拉曼光谱（SERS）检测是一个很有趣的话题，因为它具有高灵敏度、微型化和在线检测等优点。在这项工作中，我们报道了一种基于 DEP 的银纳米线聚集的 SERS 检测。在 DEP 调制下，自然产生的银纳米线聚集纳米间隙中，微流控中的分子的拉曼强度得到了极大的增强。首先，我们研究了 DEP 电压和时间对银纳米线聚集的影响，以确定 SERS 的最佳条件。然后，我们研究了不同浓度的亚甲蓝和罗丹明 6G 的 SERS 强度，结果具有很高的重现性和均匀性。此外，实验数据表明，这种 DEP-SERS 系统可用于不同分子的重复检测。最后，我们测量了三聚氰胺的 SERS，以探索其在食品安全检测中的应用。我们的工作预计这种具有高灵敏度的纳米线辅助可重复 DEP-SERS 检测在微流控中能够满足环境污染监测、食品安全评估等新兴需求。
