Sakamoto K
Dept. of Radiology, Tohoku Univ. School of Med.
Gan No Rinsho. 1988 Oct;34(13):1823-31.
Conventional radiations such as photons, gamma rays or electrons show several physical or biological disadvantages to bring tumors to cure, therefore, more and more attentions is being paid to new modality such as fast neurons, protons, negative pions and heavy ions, which are expected to overcome some of the defects of the conventional radiations. Except for fast neutrons, these particle radiations show excellent physical dose localization in tissue, moreover, in terms of biological effects, they demonstrate several features compared to conventional radiations, namely low oxygen enhancement ratio, high value of relative biological effectiveness, smaller cellular recovery, larger therapeutic gain factor and less cell cycle dependency in radiation sensitivity. In present paper the biological effects of particle radiations are shown comparing to the effect of conventional radiations.
传统辐射，如光子、伽马射线或电子，在治愈肿瘤方面存在若干物理或生物学劣势，因此，人们越来越关注诸如快中子、质子、负p介子和重离子等新的辐射方式，期望它们能克服传统辐射的一些缺陷。除快中子外，这些粒子辐射在组织中显示出优异的物理剂量定位，此外，就生物学效应而言，与传统辐射相比，它们表现出若干特征，即低氧增强比、高相对生物学效应值、较小的细胞修复、较大的治疗增益因子以及辐射敏感性对细胞周期的依赖性较小。在本文中，将粒子辐射的生物学效应与传统辐射的效应进行了比较。
