Suso L, Nogueira N, Vieira L M, Figueiredo A A, Porto J A, Sarno E N
Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro.
Med Cutan Ibero Lat Am. 1988;16(3):193-6.
The responsiveness of 25 leprosy patients to an in vitro correlate of cell-mediated immunity to M. leprae antigen, (the production of Y-IFN by peripheral blood mononuclear cells) was compared to their response to skin tests routinely used to evaluate cell-mediated immunity to a number of antigens including M. leprae. The results indicate that among the polar lepromatous patients (LL) there was a clear correlation between low responses in the in vitro assay (Y-IFN production), negative skin test to the specific antigen (Mitsuda reaction) and low responses to skin tests to a related antigen (PPD). There was no correlation in the other clinical groups with skin tests to other unrelated antigens.
将25名麻风病患者对麻风杆菌抗原细胞介导免疫的体外相关指标（外周血单核细胞产生γ-干扰素）的反应，与其对常规用于评估对包括麻风杆菌在内的多种抗原的细胞介导免疫的皮肤试验的反应进行了比较。结果表明，在极重度麻风瘤型患者（LL）中，体外试验（γ-干扰素产生）反应低、对特异性抗原的皮肤试验（密特反应）阴性以及对相关抗原（结核菌素纯蛋白衍生物）的皮肤试验反应低之间存在明显相关性。在其他临床组中，对其他不相关抗原的皮肤试验不存在相关性。
