Lindh J, Anderson U, Britton S, De Ley M
Clin Exp Immunol. 1987 Jan;67(1):51-4.
The number of gamma-interferon producing cells in the peripheral blood of leprosy (LL and BT) patients and controls was studied by the reversed protein A plaque assay before and after exposure in vitro to Mycobacterium leprae bacilli and Epstein-Barr virus (EBV). The level of spontaneous gamma-interferon production was significantly higher in BT patients compared to LL patients and controls. Mycobacterium leprae induced a specific gamma-interferon response in lymphocytes from BT patients and from healthy contacts whereas in LL patients and non-exposed controls the response was low or non-existing. There were no significant differences in the gamma-interferon response to EBV between the above groups.
采用反向蛋白A蚀斑试验，研究了麻风病患者（LL型和BT型）及对照组外周血中γ-干扰素产生细胞在体外暴露于麻风杆菌和EB病毒（EBV）之前和之后的数量。与LL型患者及对照组相比，BT型患者的γ-干扰素自发产生水平显著更高。麻风杆菌可诱导BT型患者及健康接触者淋巴细胞产生特异性γ-干扰素应答，而LL型患者及未接触者对照组的应答较低或无应答。上述各组对EBV的γ-干扰素应答无显著差异。
