Department of Procurement and Clinical Engineering, Aarhus University Hospital, Central Denmark Region, Olof Palmes Allé 15, 8200, Aarhus, Denmark.
Department of Nuclear Medicine, Aalborg University Hospital, Aalborg, Denmark.
BMC Nephrol. 2019 Aug 22;20(1):331. doi: 10.1186/s12882-019-1511-y.
Oedema, characterized by accumulation of extracellular water (ECW), is one of the major clinical manifestations in children suffering from nephrotic syndrome (NS). The lack of a simple, inexpensive and harmless method for assessing ECW may be solved by the use of the bioelectrical impedance analysis (BIA) technique. The aims of this study were to examine whether phase angle (PA), bioelectrical impedance vector analysis (BIVA) and the impedance ratio (IR) reflect change in disease status in children with NS.
Eight children (age range: 2-10 years) with active NS (ANS group) were enrolled. In five of these (ANS* subgroup), impedance was also measured at remission (NSR group). Thirty-eight healthy children (age range: 2-10 years) were included as healthy controls (HC group). Whole-body impedance was measured with a bioimpedance spectroscopy device (Xitron 4200) with surface electrodes placed on the wrist and ankle.
Values of PA, BIVA and IR were found to be significantly lower (p-value range < 0.001 to < 0.01) in the ANS patients compared to the HC and NSR groups. No significant differences were observed between the NSR and HC groups.
The studied parameters can be used to assess change in disease status in NS patients. Data were consistent with NS being associated with expansion of ECW.
水肿是肾病综合征（NS）患儿的主要临床表现之一，其特征是细胞外液（ECW）积聚。缺乏一种简单、廉价和无害的方法来评估 ECW 可能可以通过使用生物电阻抗分析（BIA）技术来解决。本研究旨在探讨相位角（PA）、生物电阻抗矢量分析（BIVA）和阻抗比（IR）是否能反映 NS 患儿疾病状态的变化。
本研究纳入了 8 名（年龄 2-10 岁）患有活动性 NS（ANS 组）的儿童。其中 5 名（ANS*亚组）在缓解期（NSR 组）也进行了阻抗测量。38 名健康儿童（年龄 2-10 岁）作为健康对照组（HC 组）。全身阻抗采用生物阻抗谱仪（Xitron 4200）测量，腕部和踝部放置表面电极。
与 HC 组和 NSR 组相比，ANS 患儿的 PA、BIVA 和 IR 值明显降低（p 值范围<0.001 至<0.01）。NSR 组与 HC 组之间无显著差异。
所研究的参数可用于评估 NS 患者疾病状态的变化。这些数据与 NS 与 ECW 扩张有关的结论一致。
