Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital (IBIMA), Malaga University, Campus Teatinos S/N 29010, Malaga, Spain.
Instituto de Investigación Biomédica de Málaga-Plataforma BIONAND (IBIMA), Virgen de la Victoria University Hospital, 29010, Málaga, Spain.
Rev Endocr Metab Disord. 2023 Aug;24(4):751-765. doi: 10.1007/s11154-023-09817-1. Epub 2023 Jul 24.
Phase angle (PhA) is a valuable tool for evaluating the nutritional and inflammatory status, which can accompany acute and severe disorders. PhA is a cellular health biomarker, whose value is particularly substantial due to the negative consequences of these situations in the pediatric population. Relevant literature was collected with the aim of comprehensively analysing the evidence on the association between an altered PhA can serve as a predictive-marker for mortality and poor-outcomes in at-risk-pediatric patients. Understanding this relationship could have significant implications for identifying high-risk individuals and implementing timely interventions. A systematic review with meta-analysis was conducted in the primary electronic databases from inception until January 2023. Overall, four studies with a total of 740 patients were eligible for our analysis. Evidence demonstrates that PhA is associated with nutritional status, reflecting undernutrition and changes in body composition related to illness. This review suggests that PhA can indeed be used as an indicator of nutritional status and a tool for predicting prognosis, including mortality and poor-outcomes, in hospitalized pediatric patients. A low PhA was associated with a significant mortality risk [RR:1.51;95%CI (1.22-1.88),p = 0.0002;I2 = 0%,(p = 0.99)] and an increased complications risk [OR:8.17;95%CI (2.44-27.4),p = 0.0007;I2 = 44%,(p = 0.18)]. These findings highlight the importance of taking a comprehensive approach to clinical nutrition, integrating multiple evaluation aspects to establish an accurate diagnosis and personalized therapeutic plans. While PhA emerges as a valuable tool for assessing the risk of malnutrition and as a prognostic-indicator for poor-outcomes in pediatric patients. Further future studies are needed to focus on investigating this relationship in larger and diverse population to strengthen the evidence base.
相位角（PhA）是评估营养和炎症状态的有价值的工具，这种状态可能伴随急性和严重疾病。PhA 是一种细胞健康生物标志物，其价值尤为重要，因为这些情况在儿科人群中会产生负面后果。收集了相关文献，旨在全面分析 PhA 改变可作为高危儿科患者死亡和不良预后预测标志物的证据。了解这种关系对于识别高风险个体和实施及时干预可能具有重要意义。在初级电子数据库中进行了系统评价和荟萃分析，时间范围从开始到 2023 年 1 月。总体而言，有四项研究共 740 名患者符合我们的分析标准。证据表明 PhA 与营养状况相关，反映了与疾病相关的营养不良和身体成分变化。这项综述表明，PhA 确实可以用作营养状况的指标和预测预后的工具，包括住院儿科患者的死亡率和不良预后。低 PhA 与显著的死亡率风险相关 [RR：1.51；95%CI（1.22-1.88），p=0.0002；I2=0%，（p=0.99）]和并发症风险增加相关 [OR：8.17；95%CI（2.44-27.4），p=0.0007；I2=44%，（p=0.18）]。这些发现强调了采取综合临床营养方法的重要性，整合多个评估方面以建立准确的诊断和个性化治疗计划。虽然 PhA 作为评估儿科患者营养不良风险和不良预后的预测指标具有重要价值，但需要进一步的未来研究来关注在更大和更多样化的人群中研究这种关系，以加强证据基础。
