Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, New York, 14263, USA.
Developmental Therapeutics Program, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, New York, 14263, USA.
J Exp Clin Cancer Res. 2019 Aug 22;38(1):368. doi: 10.1186/s13046-019-1362-1.
Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of survivin studies in the cancer field. Many studies have provided intriguing insight into survivin's functional role in cancers, thus providing promise for survivin as a cancer therapeutic target. Despite this, moving survivin-targeting agents into and through the clinic remains a challenge. In order to address this challenge, we may need to rethink current strategies in order to develop a new mindset for targeting survivin. In this Review, we will first summarize the current survivin mechanistic studies, and then review the status of survivin cancer therapeutics, which is classified into five categories: (i) survivin-partner protein interaction inhibitors, (ii) survivin homodimerization inhibitors, (iii) survivin gene transcription inhibitors, (iv) survivin mRNA inhibitors and (v) survivin immunotherapy. We will then provide our opinions on cancer therapeutics using survivin as a target, with the goal of stimulating discussion that might facilitate translational research for discovering improved strategies and/or more effective anticancer agents that target survivin for cancer therapy.
Survivin（也称为 BIRC5）是一个知名的癌症治疗靶点。自二十多年前发现以来，将 survivin 作为癌症治疗的靶点一直是癌症领域 survivin 研究的核心目标。许多研究为 survivin 在癌症中的功能作用提供了有趣的见解，从而为 survivin 作为癌症治疗靶点提供了希望。尽管如此，将靶向 survivin 的药物推向临床仍然是一个挑战。为了应对这一挑战，我们可能需要重新思考当前的策略，以建立针对 survivin 的新思维模式。在这篇综述中，我们将首先总结目前的 survivin 机制研究，然后综述 survivin 癌症治疗的现状，分为五类：（i）survivin-伙伴蛋白相互作用抑制剂，（ii）survivin 同源二聚体抑制剂，（iii）survivin 基因转录抑制剂，（iv）survivin mRNA 抑制剂和（v）survivin 免疫疗法。然后，我们将就使用 survivin 作为靶点的癌症治疗提出我们的看法，以期激发讨论，从而促进发现改善的策略和/或更有效的针对 survivin 的抗癌药物的转化研究，用于癌症治疗。
