关于阿尔茨海默病保护性CD33剪接变体的亚细胞定位及作用机制的争议。 - Suppr | 超能文献

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Controversies about the subcellular localization and mechanisms of action of the Alzheimer's disease-protective CD33 splice variant.关于阿尔茨海默病保护性CD33剪接变体的亚细胞定位及作用机制的争议。

Acta Neuropathol. 2019 Oct;138(4):671-672. doi: 10.1007/s00401-019-02065-1. Epub 2019 Aug 22.

2

Evaluation of CD33 as a genetic risk factor for Alzheimer's disease.评估 CD33 作为阿尔茨海默病的遗传风险因素。

Acta Neuropathol. 2019 Aug;138(2):187-199. doi: 10.1007/s00401-019-02000-4. Epub 2019 Apr 4.

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The Alzheimer's disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.具有阿尔茨海默病保护作用的CD33剪接变体通过转移至细胞内池介导适应性功能丧失。

J Biol Chem. 2017 Sep 15;292(37):15312-15320. doi: 10.1074/jbc.M117.799346. Epub 2017 Jul 26.

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Alzheimer's disease CD33 rs3865444 variant does not contribute to cognitive performance.阿尔茨海默病CD33基因rs3865444变异与认知表现无关。

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1589-90. doi: 10.1073/pnas.1600852113. Epub 2016 Mar 1.

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CD33 rs2455069 SNP: Correlation with Alzheimer's Disease and Hypothesis of Functional Role.CD33 rs2455069单核苷酸多态性：与阿尔茨海默病的相关性及功能作用假说

Int J Mol Sci. 2022 Mar 26;23(7):3629. doi: 10.3390/ijms23073629.

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Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex.CD33基因多态性rs3865444与阿尔茨海默病病理学及人大脑皮质中CD33表达的关联

Neurobiol Aging. 2015 Feb;36(2):571-82. doi: 10.1016/j.neurobiolaging.2014.09.023. Epub 2014 Oct 2.

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Decreased expression of CD33 in peripheral mononuclear cells of Alzheimer's disease patients.阿尔茨海默病患者外周血单个核细胞中CD33表达降低。

Neurosci Lett. 2014 Mar 20;563:51-4. doi: 10.1016/j.neulet.2014.01.004. Epub 2014 Jan 9.

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The CD33 genotype associated cognitive performance was bidirectionally modulated by intrinsic functional connectivity in the Alzheimer's disease spectrum.CD33 基因型与认知表现相关，这种相关性在阿尔茨海默病谱中受到内在功能连接的双向调节。

Biomed Pharmacother. 2019 Jul;115:108903. doi: 10.1016/j.biopha.2019.108903. Epub 2019 May 1.

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CD33 in Alzheimer's Disease - Biology, Pathogenesis, and Therapeutics: A Mini-Review.阿尔茨海默病中的 CD33 - 生物学、发病机制和治疗学：综述。

Gerontology. 2019;65(4):323-331. doi: 10.1159/000492596. Epub 2018 Dec 12.

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Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline.CD33及其他基因的人类特异性衍生等位基因可预防生殖后期认知能力下降。

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):74-9. doi: 10.1073/pnas.1517951112. Epub 2015 Nov 30.

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Does SIGLEC8 localize to the subcellular compartment like the Alzheimer's disease protective CD33 splice variant?信号淋巴细胞激活分子8（SIGLEC8）是否像阿尔茨海默病保护性CD33剪接变体一样定位于亚细胞区室？

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Evolution of Human-Specific Alleles Protecting Cognitive Function of Grandmothers.人类特有的等位基因保护祖母认知功能的进化。

Mol Biol Evol. 2022 Aug 3;39(8). doi: 10.1093/molbev/msac151.

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The CD33 short isoform is a gain-of-function variant that enhances Aβ phagocytosis in microglia.