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[肺动脉高压和慢性肺病患者的心律失常]

[Arrhythmias in patients with pulmonary hypertension and chronic lung disease].

作者信息

Bandorski Dirk, Höltgen Reinhard, Ghofrani Ardeschir, Johnson Viktoria, Schmitt Jörn

机构信息

Medizinische Fakultät, Semmelweis Universität, Campus Hamburg, Lohmühlenstraße 5/Haus P, 20099, Hamburg, Deutschland.

Intensivmedizin und internistische Diagnostik, Asklepios Neurologische Klinik Bad Salzhausen, Am Hasensprung 6, 63667, Nidda, Deutschland.

出版信息

Herzschrittmacherther Elektrophysiol. 2019 Sep;30(3):234-239. doi: 10.1007/s00399-019-00637-y. Epub 2019 Aug 22.

Abstract

Pulmonary arterial hypertension (PAH) occurs in 1% of the global population and can be divided in different disease groups. Pathophysiological aspects leading to supraventricular arrhythmias in these patients are due to increased pulmonary and right atrial pressure, increased activity of the sympathetic nervous system leading to right atrial electrical remodeling and ischemia in the right atrium. In the clinical setting these patients present with atrial flutter, atrial fibrillation or with ectopic atrial tachycardia. Regarding ventricular tachycardia there is a lack of data. Occurrence of arrhythmia in these patients leads to a deterioration of PAH, so rhythm control should be the aim. This can be achieved by right atrial ablation, especially in patients presenting with atrial flutter; electric cardioversion or antiarrhythmic drug therapy are without definite guideline recommendations since there are too few clinical trials. Ablation with a transseptal approach in the left atrium is considered rather dangerous and should be avoided. Regarding arrhythmias in patients with chronic lung disease, few data are available. For patients with chronic obstructive pulmonary disease (COPD), there are good data available. These patients often suffer from coronary heart disease, atrial fibrillation, and ventricular tachycardia. Beta-blockers play an important role in COPD patients, even during exacerbation. Interventional therapies are safe but the arrhythmogenic foci often located outside of the pulmonary veins (in the right atrium).

摘要

肺动脉高压(PAH)在全球1%的人口中出现,并且可分为不同的疾病组。导致这些患者室上性心律失常的病理生理方面是由于肺和右心房压力增加、交感神经系统活性增加导致右心房电重构以及右心房缺血。在临床环境中,这些患者表现为心房扑动、心房颤动或异位房性心动过速。关于室性心动过速,缺乏相关数据。这些患者心律失常的发生会导致PAH恶化,因此节律控制应是目标。这可通过右心房消融来实现,特别是对于表现为心房扑动的患者;由于临床试验太少,电复律或抗心律失常药物治疗尚无明确的指南推荐。经房间隔途径在左心房进行消融被认为相当危险,应予以避免。关于慢性肺病患者的心律失常,可用数据很少。对于慢性阻塞性肺疾病(COPD)患者,有可用的良好数据。这些患者常患有冠心病、心房颤动和室性心动过速。β受体阻滞剂在COPD患者中起重要作用,即使在病情加重期间也是如此。介入治疗是安全的,但心律失常起源灶通常位于肺静脉之外(在右心房)。

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