[正常角膜与圆锥角膜之间的粘弹性比较研究]
[A comparative study of viscoelasticity between normal cornea and keratoconus].
作者信息
Zhao Kechao, Wang Xiaojun, Chen Weiyi, He Rui, Li Xiaona, Gao Yan
机构信息
School of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P.R.China.
School of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P.R.China;School of Mechanical and Transportation Engineering, Taiyuan University of Technology, Taiyuan 030024,
出版信息
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2019 Aug 25;36(4):613-618. doi: 10.7507/1001-5515.201812052.
Study of the mechanical properties of in vivo corneal materials is an important basis for further study of corneal physiological and pathological phenomena by means of finite element method. In this paper, the elastic coefficient ( ) and viscous coefficient ( ) of normal cornea and keratoconus under pulse pressure are calculated by using standard linear solid model with the data provided by corneal visualization scheimpflug technology. The results showed that there was a significant difference of and between normal cornea and keratoconus cornea ( < 0.05). Receiver operating characteristic curve analysis showed that the area under curve (AUC) for , and their combined indicators were 0.776, 0.895 and 0.948, respectively, which indicated that keratoconus could be predicted by and . The results of this study may provide a reference for the early diagnosis of keratoconus and avoid the occurrence of keratoconus after operation, so it has a certain clinical value.
研究体内角膜材料的力学性能是借助有限元方法进一步研究角膜生理和病理现象的重要基础。本文利用角膜可视化Scheimpflug技术提供的数据，采用标准线性固体模型计算了正常角膜和圆锥角膜在脉冲压力下的弹性系数（ ）和粘性系数（ ）。结果显示，正常角膜和圆锥角膜的 和 存在显著差异（ < 0.05）。受试者工作特征曲线分析表明， 、 及其联合指标的曲线下面积（AUC）分别为0.776、0.895和0.948，这表明 和 可用于预测圆锥角膜。本研究结果可为圆锥角膜的早期诊断提供参考，避免术后圆锥角膜的发生，具有一定的临床价值。
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