Simonini Irene, Pandolfi Anna
Mathematics Department, Politecnico di Milano, Piazza Leonardo Da Vinci 32, 20133, Italy.
Civil and Environmental Engineering Department, Politecnico di Milano, Piazza Leonardo Da Vinci 32, 20133, Italy.
J Mech Behav Biomed Mater. 2016 May;58:75-89. doi: 10.1016/j.jmbbm.2015.07.030. Epub 2015 Aug 3.
The air puff is a dynamic contactless tonometer test used in ophthalmology clinical practice to assess the biomechanical properties of the human cornea and the intraocular pressure due to the filling fluids of the eye. The test is controversial, since the dynamic response of the cornea is governed by the interaction of several factors which cannot be discerned within a single measurement. In this study we describe a numerical model of the air puff tests, and perform a parametric analysis on the major action parameters (jet pressure and intraocular pressure) to assess their relevance on the mechanical response of a patient-specific cornea. The particular cornea considered here has been treated with laser reprofiling to correct myopia, and the parametric study has been conducted on both the preoperative and postoperative geometries. The material properties of the cornea have been obtained by means of an identification procedure that compares the static biomechanical response of preoperative and postoperative corneas under the physiological IOP. The parametric study on the intraocular pressure suggests that the displacement of the cornea׳s apex can be a reliable indicator for tonometry, and the one on the air jet pressure predicts the outcomes of two or more distinct measurements on the same cornea, which can be used in inverse procedures to estimate the material properties of the tissue.
气流冲击眼压测量法是眼科临床实践中使用的一种动态非接触眼压计测试,用于评估人类角膜的生物力学特性以及因眼内填充液产生的眼压。该测试存在争议,因为角膜的动态响应受多种因素相互作用的支配,而这些因素无法在单次测量中辨别出来。在本研究中,我们描述了气流冲击测试的数值模型,并对主要作用参数(喷射压力和眼压)进行了参数分析,以评估它们对特定患者角膜力学响应的相关性。这里所考虑的特定角膜已经过激光重塑治疗以矫正近视,并且对术前和术后的几何形状都进行了参数研究。角膜的材料特性是通过一种识别程序获得的,该程序比较了术前和术后角膜在生理眼压下的静态生物力学响应。关于眼压的参数研究表明,角膜顶点的位移可以作为眼压测量的可靠指标,而关于气流喷射压力的参数研究预测了在同一角膜上进行的两次或更多次不同测量的结果,这些结果可用于反向程序以估计组织的材料特性。