Davis A T, Albrecht R M, Scholten D J, Morgan R E
Department of Surgery, Michigan State University, Grand Rapids.
Am J Clin Nutr. 1988 Dec;48(6):1400-2. doi: 10.1093/ajcn/48.6.1400.
The purpose of this study was to determine the effects of altering the fuel substrate mix of total parenteral nutrition (TPN) on plasma and urinary carnitine in trauma patients. TPN solutions were either 100% carbohydrate (CHO) based or lipid based (70% CHO, 30% lipid). There were statistically significant (p less than 0.05) increases in plasma levels of free carnitine, short-chain acyl carnitine, and total carnitine in trauma patients receiving lipid-based TPN. No significant differences in urinary carnitine excretion were noted between groups. We conclude that the use of lipids in the TPN of trauma patients leads to an alteration in plasma carnitine metabolism.
本研究的目的是确定改变创伤患者全胃肠外营养（TPN）的燃料底物组合对血浆和尿中肉碱的影响。TPN溶液要么是以100%碳水化合物（CHO）为基础，要么是以脂质为基础（70%CHO，30%脂质）。接受基于脂质的TPN的创伤患者，其游离肉碱、短链酰基肉碱和总肉碱的血浆水平有统计学显著升高（p小于0.05）。两组之间尿肉碱排泄无显著差异。我们得出结论，创伤患者TPN中使用脂质会导致血浆肉碱代谢改变。
