Department of Hygiene and Health Promotion, Medical University of Lodz, ul. Żeligowskiego 7/9, 90-752 Łódź, Poland.
Department of Hygiene and Health Promotion, Medical University of Lodz, ul. Żeligowskiego 7/9, 90-752 Łódź, Poland.
Arch Oral Biol. 2019 Nov;107:104515. doi: 10.1016/j.archoralbio.2019.104515. Epub 2019 Aug 5.
The aim of this study was to evaluate the salivary C-reactive protein and native and non-urate total antioxidant capacity (TAC) of saliva and plasma in relation to various oral health status indexes in older non-smoking adults.
Oral health status indices involved the Decayed, Missing, Filled Teeth index, the number of decayed teeth, Approximal Plaque Index, Plaque Index and Community Periodontal Index with Treatment Needs. Sixty older patients (67.0 ± 4.5 years) with different levels of oral health were examined. Salivary C-reactive protein was assessed. The Ferric Reducing Ability of Saliva/Plasma (FRAS/FRAP) and 2.2-diphenyl-1-picryl-hydrazyl test of saliva/plasma (DPPHS/DPPH) were used to assess the native and non-urate salivary (FRAS, non-urate FRAS, DPPHS, non-urate DPPHS, and plasma TAC (FRAP, non-urate FRAP, DPPH, non-urate DPPH).
Salivary C-reactive protein, native TAC and non-urate TAC did not correspond to any oral health status index. No relation was found for plasma native and non-urate TAC either. In multivariate analyses, age was the only independent predictor of DPPHS and salivary uric acid (p < 0.05) while non-urate DPPH was only negatively predicted by Body Mass Index (p < 0.001). None of oral health status indices was selected as an independent predictor of salivary and plasma TAC or C-reactive protein of saliva.
Oral health status indexes did not appear to influence the native or the non-urate local antioxidant status of saliva, or the systemic antioxidant status of plasma; they had no local effect related to salivary C-reactive protein. However, lower plasma non-urate antioxidant potential was related to overweight/obesity.
本研究旨在评估唾液 C-反应蛋白（CRP）以及唾液和血浆中原位和非尿酸总抗氧化能力（TAC）与老年不吸烟成年人各种口腔健康状况指标的关系。
口腔健康状况指标包括龋齿、缺失、补牙指数、龋齿数、近中斑块指数、菌斑指数和社区牙周指数（需要治疗）。共检查了 60 名年龄在 67.0±4.5 岁、口腔健康状况不同的老年患者。评估了唾液 CRP。采用唾液/血浆铁还原能力（FRAS/FRAP）和唾液/血浆 2.2-二苯基-1-苦肼基自由基测试（DPPHS/DPPH）评估唾液中原位和非尿酸 TAC（FRAS、非尿酸 FRAS、DPPHS、非尿酸 DPPHS 和血浆 TAC（FRAP、非尿酸 FRAP、DPPH、非尿酸 DPPH）。
唾液 CRP、原位 TAC 和非尿酸 TAC 与任何口腔健康状况指标均无相关性。血浆中原位和非尿酸 TAC 也没有相关性。多元分析显示，年龄是 DPPHS 和唾液尿酸的唯一独立预测因子（p<0.05），而非尿酸 DPPH 仅受体重指数的负向预测（p<0.001）。口腔健康状况指标均未被选为唾液和血浆 TAC 或唾液 CRP 的独立预测因子。
口腔健康状况指标似乎不会影响唾液中原位或非尿酸局部抗氧化状态，也不会影响血浆的系统抗氧化状态；它们与唾液 CRP 无局部作用。然而，较低的血浆非尿酸抗氧化能力与超重/肥胖有关。
