Farahmand Amirhossein, Talebi Marjan, Ramezani Farzaneh, Karami Roghayeh, Jafari Nodoushani Zahra, Alsadat Ayatollahi Neda, Abdulmajid Ayatollahi Seyed, Alaee Arezoo
Department of Periodontics, Faculty of Dentistry, Borujerd Medical Sciences, Islamic Azad University, Lorestan, Iran.
Student Research Committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saudi Dent J. 2024 Dec;36(12):1509-1514. doi: 10.1016/j.sdentj.2024.09.014. Epub 2024 Sep 12.
The dental community has shown interest in the potential of Omega-3 and coenzyme Q10 for reducing inflammation in the periodontium. These antioxidant agents may enhance the outcomes of non-surgical periodontal treatments. This study aimed to investigate the potential benefits of CoQ10 and Omega-3 supplements in improving periodontal health and the TAC of saliva in individuals with chronic periodontitis.
In a double-blind, randomized clinical trial, 75 individuals were diagnosed with chronic periodontitis. These individuals were randomly allocated into three groups. The periodontal examination involved a total of 300 teeth across the three groups. The periodontal parameters of the two molars adjacent to the mandible were measured using a periodontal probe. All patients underwent scaling and root planing. Groups A and B received CoQ10 and Omega-3 respectively, while Group C served as the control. The TAC of the non-stimulated saliva samples was evaluated to assess any changes before and after 2 months. Statistical techniques were employed to compare the CAL index and PPD between the groups under study.
The analysis of the gingival index indicated a notable reduction in inflammation within the Omega-3 group compared to both the CoQ10 and control groups, with a nearly 30% decrease observed. Furthermore, the bleeding on probing index within the Omega-3 group demonstrated significant improvements when contrasted with the CoQ10 and control groups, with this decrease being statistically significant. Additionally, the levels of TAC in the patients' saliva across all three groups exhibited changes when compared to the initial measurements.
These findings provide valuable insights into the potential therapeutic effects of Omega-3 and CoQ10 supplementation on periodontal health and the antioxidant capacity of saliva.
牙科界已对欧米伽-3和辅酶Q10在减轻牙周组织炎症方面的潜力表现出兴趣。这些抗氧化剂可能会提高非手术牙周治疗的效果。本研究旨在调查辅酶Q10和欧米伽-3补充剂对改善慢性牙周炎患者牙周健康和唾液总抗氧化能力（TAC）的潜在益处。
在一项双盲随机临床试验中，75名个体被诊断为慢性牙周炎。这些个体被随机分为三组。牙周检查涉及三组共300颗牙齿。使用牙周探针测量下颌相邻两颗磨牙的牙周参数。所有患者均接受了龈下刮治和根面平整。A组和B组分别接受辅酶Q10和欧米伽-3，而C组作为对照组。评估非刺激性唾液样本的TAC，以评估2个月前后的任何变化。采用统计技术比较研究组之间的临床附着丧失（CAL）指数和探诊深度（PPD）。
牙龈指数分析表明，与辅酶Q10组和对照组相比，欧米伽-3组的炎症明显减轻，观察到近30%的下降。此外，与辅酶Q10组和对照组相比，欧米伽-3组的探诊出血指数有显著改善，这种下降具有统计学意义。此外，与初始测量值相比，所有三组患者唾液中的TAC水平均出现了变化。
这些发现为欧米伽-3和辅酶Q10补充剂对牙周健康和唾液抗氧化能力的潜在治疗作用提供了有价值的见解。
