National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
J Trace Elem Med Biol. 2019 Dec;56:6-12. doi: 10.1016/j.jtemb.2019.07.003. Epub 2019 Jul 10.
The association between plasma selenium and new-onset diabetes in hypertensive adults is still unclear. We aimed to evaluate the relationship of baseline plasma selenium with new-onset diabetes and examine possible effect modifiers in a post-hoc analysis of the China Stroke Primary Prevention Trial (CSPPT).
A total of 2367 hypertensive, non-diabetic patients with plasma selenium measurements at baseline were included. The primary outcome was new-onset diabetes, defined as physician-diagnosed diabetes or use of glucose-lowering drugs during the follow-up period, or fasting glucose (FG) ≥126.0 mg/dL at the exit visit.
At baseline, higher FG levels were found among participants with plasma selenium in quartile 4 (≥94.8 μg/L) (β, 1.64 mg/dL; 95%CI: 0.54, 2.73) compared to those in quartiles 1-3. During a median follow-up duration of 4.5 years, new-onset diabetes occurred in 270 (11.4%) participants. Graphic plot showed a positive association between baseline selenium levels and risk of new-onset diabetes. This was further confirmed by adjusted regression analyses; the odds ratios (OR) for new-onset diabetes comparing quartile 4 (≥94.8 μg/L) to quartiles 1-3 was 1.36 (95%CI: 1.01, 1.83). No clear trend was evident across quartiles 1-3.
Our data suggest that high plasma selenium (≥94.8 μg/L) was associated with increased risk of new-onset diabetes in hypertensive patients.
血浆硒与高血压成年人新发糖尿病之间的关系尚不清楚。我们旨在评估基线血浆硒与新发糖尿病的关系，并在后中国脑卒中一级预防试验（CSPPT）的事后分析中检查可能的调节因素。
共纳入 2367 名基线时测量血浆硒的高血压、非糖尿病患者。主要结局是新发糖尿病，定义为医生诊断的糖尿病或在随访期间使用降血糖药物，或在退出访视时空腹血糖（FG）≥126.0mg/dL。
基线时，第 4 四分位（≥94.8μg/L）的参与者 FG 水平较高（β，1.64mg/dL；95%CI：0.54，2.73）与第 1-3 四分位相比。在中位数为 4.5 年的随访期间，270 名（11.4%）参与者发生新发糖尿病。图形显示基线硒水平与新发糖尿病风险之间存在正相关。这通过调整后的回归分析进一步得到证实；与四分位数 1-3 相比，第 4 四分位（≥94.8μg/L）发生新发糖尿病的比值比（OR）为 1.36（95%CI：1.01，1.83）。在四分位数 1-3 中没有明显的趋势。
我们的数据表明，高血压患者血浆硒水平较高（≥94.8μg/L）与新发糖尿病风险增加相关。
