Bernstock Joshua D, Mooney James H, Ilyas Adeel, Chagoya Gustavo, Estevez-Ordonez Dagoberto, Ibrahim Ahmed, Nakano Ichiro
1Department of Neurosurgery.
2Medical Scientist Training Program, and.
J Neurosurg. 2019 Aug 23;133(3):655-663. doi: 10.3171/2019.5.JNS19364. Print 2020 Sep 1.
Glioblastoma (GBM), the most common primary malignant brain tumor in adults, is associated with significant morbidity and mortality despite maximal safe resection followed by chemo- and radiotherapy. GBMs contain self-renewing, tumorigenic glioma stem cells that contribute to tumor initiation, heterogeneity, therapeutic resistance, and recurrence. Intratumoral heterogeneity (ITH) of GBMs is also a major contributing factor to poor clinical outcomes associated with these high-grade glial tumors. Herein, the authors summarize recent discoveries and advances in the molecular and phenotypic characterization of GBMs with particular focus on ITH. In so doing, they attempt to highlight recent advances in molecular signatures/properties and metabolic alterations in an effort to clarify translational implications that may ultimately improve clinical outcomes.
胶质母细胞瘤（GBM）是成人中最常见的原发性恶性脑肿瘤，尽管进行了最大程度的安全切除，随后进行了化疗和放疗，但其发病率和死亡率仍然很高。GBM包含自我更新、具有致瘤性的胶质瘤干细胞，这些干细胞导致肿瘤的起始、异质性、治疗抗性和复发。GBM的肿瘤内异质性（ITH）也是导致这些高级别胶质瘤临床预后不良的主要因素。在此，作者总结了GBM分子和表型特征方面的最新发现和进展，特别关注ITH。通过这样做，他们试图突出分子特征/特性和代谢改变方面的最新进展，以阐明可能最终改善临床预后的转化意义。
