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乳房切除术还是保乳手术:由患者选择。

Mastectomy or conservation: the patient's choice.

作者信息

Wilson R G, Hart A, Dawes P J

机构信息

Newcastle General Hospital, Newcastle upon Tyne.

出版信息

BMJ. 1988 Nov 5;297(6657):1167-9. doi: 10.1136/bmj.297.6657.1167.

Abstract

STUDY OBJECTIVE

To determine whether, if given the choice, patients with breast cancer would prefer mastectomy or conservation treatment, neither treatment having been shown to be preferable.

DESIGN

Non-randomised case series with 28 patients interviewed after two years and all followed up.

SETTING

Secondary care referral centre.

PATIENTS

153 women, aged less than 65, with T1, T2, N1, and N0 tumours of the breast given the choice of treatment (that is, all eligible patients from December 1979).

INTERVENTIONS

Patients were asked, after information and counselling, which treatment they would prefer. The chosen treatment was given without further question. Mastectomy included node sampling and local radiotherapy if indicated. Conservation treatment comprised excision of the lump, external radiotherapy, and irridium wire implant to tumour bed.

MAIN RESULTS

Conservation treatment was chosen by 54 women and mastectomy by 99. Reasons for preferring mastectomy included desire for rapid treatment for domestic or employment reasons and fear of possibility of future mastectomy. Only two of the sample interviewed regretted their choice. During limited follow up no advantages to either form of treatment were seen in terms of recurrence or survival.

CONCLUSIONS

Patients with breast cancer are capable of choosing treatment and should play a part in deciding which treatment to have. They do not automatically choose to retain the breast.

摘要

研究目的

确定如果可以选择,乳腺癌患者会更倾向于乳房切除术还是保乳治疗,这两种治疗方法均未显示出更具优势。

设计

非随机病例系列研究,对28例患者进行了两年后的访谈并进行了全程随访。

地点

二级医疗转诊中心。

患者

153名年龄小于65岁、患有T1、T2、N1和N0期乳腺肿瘤的女性,她们可选择治疗方式(即1979年12月以来的所有符合条件的患者)。

干预措施

在提供信息和咨询后,询问患者倾向于哪种治疗方法。患者选择的治疗方法直接采用,不再追问。乳房切除术包括根据情况进行淋巴结取样和局部放疗。保乳治疗包括肿块切除、体外放疗以及在肿瘤床植入铱丝。

主要结果

54名女性选择了保乳治疗,99名选择了乳房切除术。倾向于乳房切除术的原因包括出于家庭或工作原因希望快速治疗以及担心未来可能需要进行乳房切除术。在接受访谈的样本中,只有两人对自己的选择感到后悔。在有限的随访期间,在复发或生存方面,两种治疗方式均未显示出优势。

结论

乳腺癌患者有能力选择治疗方法,并且应该参与决定接受哪种治疗。她们不会自动选择保留乳房。

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