State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, China.
College of Biotechnology, Southwest University, Chongqing 400715, China.
Cells. 2019 Aug 22;8(9):955. doi: 10.3390/cells8090955.
Phosphoribosyl pyrophosphate synthetase 1 (PRPS1) is a key enzyme in de novo nucleotide synthesis and nucleotide salvage synthesis pathways that are critical for purine and pyrimidine biosynthesis. Abnormally high expression of PRPS1 can cause many diseases, including hearing loss, hypotonia, and ataxia, in addition to being associated with neuroblastoma. However, the role of PRPS1 in neuroblastoma is still unclear. In this study, we found that PRPS1 was commonly expressed in neuroblastoma cells and was closely related to poor prognosis for cancer. Furthermore, down-regulation of PRPS1 inhibited neuroblastoma cell proliferation and tumor growth in vitro and in vivo via disturbing DNA synthesis. This study provides new insights into the treatment of neuroblastoma patients and new targets for drug development.
磷酸核糖焦磷酸合成酶 1（PRPS1）是从头合成途径和核苷酸补救合成途径中的关键酶，这些途径对嘌呤和嘧啶生物合成至关重要。PRPS1 的异常高表达可导致多种疾病，包括听力损失、张力减退和共济失调，此外还与神经母细胞瘤有关。然而，PRPS1 在神经母细胞瘤中的作用尚不清楚。在这项研究中，我们发现 PRPS1 在神经母细胞瘤细胞中普遍表达，并且与癌症的不良预后密切相关。此外，下调 PRPS1 通过干扰 DNA 合成来抑制神经母细胞瘤细胞的体外和体内增殖和肿瘤生长。这项研究为神经母细胞瘤患者的治疗提供了新的见解，并为药物开发提供了新的靶点。
