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皮质螺钉与传统椎弓根螺钉治疗腰椎体间融合的疗效比较:系统评价和荟萃分析。

Comparison of outcomes between cortical screws and traditional pedicle screws for lumbar interbody fusion: a systematic review and meta-analysis.

机构信息

Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, 148 Baojian Road, Harbin, 150081, China.

Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, China.

出版信息

J Orthop Surg Res. 2019 Aug 23;14(1):269. doi: 10.1186/s13018-019-1311-x.

Abstract

PURPOSE

The clinical outcomes of using a cortical screw (CS) for lumbar interbody fusion were evaluated by comparison with conventional pedicle screw (PS) fixation.

METHODS

All of the comparative studies published in the PubMed, Cochrane Library, MEDLINE, Web of Science, and EMBASE databases recently as 18 March 2019, were included. All outcomes were analyzed by using Review Manager 5.3.

RESULTS

Twelve studies were included with a total of 835 patients, and two of the studies were randomized controlled trials. The outcomes of the meta-analysis indicated that the use of CS fixation for lumbar interbody fusion was better than conventional PS fixation in regard to operating time (p = 0.02), intraoperative blood loss (p < 0.00001), length of stay (p = 0.02), incidence of complications (p = 0.02), adjacent segmental disease (ASD) incidence (p = 0.03), and Oswestry Disability Index (ODI) (p = 0.03). However, there were no statistically significant differences in the back and leg pain visual analog scale (VAS), Japanese Orthopaedic Association (JOA) scale, and intervertebral fusion rate (all p > 0.05) between the CS fixation group and the PS fixation group.

CONCLUSIONS

Based on this systematic review and meta-analysis, our outcomes indicated that both CS and conventional PS can result in good postoperative outcomes in lumbar interbody fusion. No significant differences were found in the back and leg pain VAS, JOA scale, and intervertebral fusion rate. However, CS fixation is superior to PS fixation in the following measures: operating time, intraoperative blood loss, length of stay, incidence of complications, ASD incidence, and ODI.

TRIAL REGISTRATION

PROSPERO registration number is CRD 42019132226 .

摘要

目的

通过与传统经皮椎弓根螺钉(PS)固定的比较,评估皮质骨螺钉(CS)在腰椎椎间融合中的临床疗效。

方法

检索 2019 年 3 月 18 日前在 PubMed、Cochrane 图书馆、MEDLINE、Web of Science 和 EMBASE 数据库中发表的所有比较研究。使用 Review Manager 5.3 分析所有结果。

结果

共纳入 12 项研究,共计 835 例患者,其中 2 项研究为随机对照试验。荟萃分析结果表明,CS 固定组在手术时间(p=0.02)、术中出血量(p<0.00001)、住院时间(p=0.02)、并发症发生率(p=0.02)、邻近节段疾病(ASD)发生率(p=0.03)和 Oswestry 残疾指数(ODI)(p=0.03)方面均优于传统 PS 固定组。但 CS 固定组与 PS 固定组在腰背疼痛视觉模拟评分(VAS)、日本骨科协会(JOA)评分和椎间融合率方面差异均无统计学意义(均 p>0.05)。

结论

基于本次系统评价和荟萃分析,CS 和传统 PS 均能获得良好的腰椎椎间融合术后效果,在腰背疼痛 VAS、JOA 评分和椎间融合率方面无显著差异。但 CS 固定在手术时间、术中出血量、住院时间、并发症发生率、ASD 发生率和 ODI 方面优于 PS 固定。

试验注册

PROSPERO 注册号为 CRD 42019132226。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6c2/6708162/fdbff8ab7030/13018_2019_1311_Fig1_HTML.jpg

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