Turku Bioscience Centre, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland.
Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, 20520 Turku, Finland.
Essays Biochem. 2019 Oct 31;63(5):535-551. doi: 10.1042/EBC20190012.
The ability of cells to migrate is a fundamental physiological process involved in embryonic development, tissue homeostasis, immune surveillance and wound healing. In order for cells to migrate, they must interact with their environment using adhesion receptors, such as integrins, and form specialized adhesion complexes that mediate responses to different extracellular cues. In this review, we discuss the role of integrin adhesion complexes (IACs) in cell migration, highlighting the layers of regulation that are involved, including intracellular signalling cascades, mechanosensing and reciprocal feedback to the extracellular environment. We also discuss the role of IACs in extracellular matrix remodeling and how they impact upon cell migration.
细胞迁移能力是胚胎发育、组织内稳态、免疫监视和伤口愈合等基本生理过程所必需的。为了使细胞能够迁移，它们必须通过细胞表面的黏附受体（如整合素）与环境相互作用，并形成专门的黏附复合物，以介导对不同细胞外信号的反应。在这篇综述中，我们讨论了整合素黏附复合物（IACs）在细胞迁移中的作用，重点介绍了涉及的调节层次，包括细胞内信号级联、机械感知以及对细胞外环境的反馈。我们还讨论了 IACs 在细胞外基质重塑中的作用，以及它们如何影响细胞迁移。
