Hou Xiaoting, Ren Chang, Jin Jing, Chen Yu, Lyu Xinyu, Bi Kangle, Carrillo Noah D, Cryns Vincent L, Anderson Richard A, Sun Jichao, Chen Mo
Department of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Nat Cell Biol. 2025 May;27(5):736-748. doi: 10.1038/s41556-025-01647-4. Epub 2025 Apr 1.
Cell motility and adhesion are fundamental components for diverse physiological functions, including embryonic development, immune responses and tissue repair. Dysregulation of these processes can lead to a range of diseases, including cancer. Cell motility and adhesion are complex and often require regulation by an intricate network of signalling pathways, with phosphatidylinositol phosphates (PIPs) having a central role. PIPs are derived from phosphatidylinositol phosphorylation and are instrumental in mediating membrane dynamics, intracellular trafficking, cytoskeletal organization and signal transduction, all of which are crucial for cellular responses to environmental stimuli. Here we discuss the mechanisms through which PIPs modulate cell motility and adhesion by examining their roles at focal adhesions, within the cytoskeleton, at protein scaffolds and in the nucleus. By providing a comprehensive overview of PIP signalling, this Review underscores their significance in maintaining cellular homeostasis and highlights their potential as therapeutic targets in diseases characterized by aberrant cell motility and adhesion.
细胞运动性和黏附是多种生理功能的基本组成部分，包括胚胎发育、免疫反应和组织修复。这些过程的失调会导致一系列疾病，包括癌症。细胞运动性和黏附是复杂的，通常需要由一个错综复杂的信号通路网络进行调节，其中磷脂酰肌醇磷酸（PIPs）起着核心作用。PIPs来源于磷脂酰肌醇的磷酸化，在介导膜动力学、细胞内运输、细胞骨架组织和信号转导中发挥作用，所有这些对于细胞对环境刺激的反应都至关重要。在这里，我们通过研究PIPs在黏着斑、细胞骨架内、蛋白质支架和细胞核中的作用，来讨论PIPs调节细胞运动性和黏附的机制。通过全面概述PIP信号传导，本综述强调了它们在维持细胞稳态中的重要性，并突出了它们作为以异常细胞运动性和黏附为特征的疾病治疗靶点的潜力。
