Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, Claremont Crescent, Sheffield, UK.
Department of Oral and Maxillofacial Surgery, Charles Clifford Dental Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Wellesley Road, Sheffield, UK.
Br Dent J. 2019 Aug;227(4):281-284. doi: 10.1038/s41415-019-0622-y.
Introduction The injection of dermal fillers into orofacial tissues is becoming increasingly popular for cosmetic purposes, in particular for lip augmentation. Both natural and synthetic filler materials are available, producing a spectrum of clinical and histological appearances.Aims The aim of this study was to review the clinicopathological characteristics of dermal filler cases from 2006 to 2016, reported at a specialist oral pathology unit.Methods An archival search of the pathology database was performed to retrieve cases reported as being consistent with cosmetic fillers.Results Ten cases of orofacial cosmetic fillers were retrieved. Of these cases, 100% were from female patients and the mean age of presentation was 47.6 years (range 24-68 years). The lips were the most frequently involved site (80%, n = 8). The majority of provisional diagnoses were related to salivary gland disease, including neoplasms (30%, n = 3), cysts (20%, n = 2) or inflammatory disease (10%, n = 1). Only two cases (20%) were clinically thought to be related to previous cosmetic injections. A variety of filler materials were seen, including collagen, hydroxyapatite and silicone. However, hyaluronic acid-based materials were the most common (50%, n = 5).Conclusions Complications of cosmetic dermal fillers are becoming more common and should be considered within a differential diagnosis for unusual orofacial swellings.
简介 向口腔组织内注射真皮填充剂，已成为一种日益流行的美容手段，尤其用于丰唇。目前既有天然填充物，也有合成填充物，其产生的临床和组织学表现各有不同。 目的 本研究旨在回顾 2006 年至 2016 年期间，一家口腔病理专科机构报告的真皮填充剂病例的临床病理特征。 方法 对病理数据库进行了存档检索，以获取符合美容填充剂的病例报告。 结果 共检索到 10 例口腔美容填充物病例。这些病例均来自女性患者，占比 100%，就诊时的平均年龄为 47.6 岁（24-68 岁）。最常累及的部位是嘴唇（80%，n=8）。大多数临时诊断与唾液腺疾病相关，包括肿瘤（30%，n=3）、囊肿（20%，n=2）或炎症性疾病（10%，n=1）。只有 2 例（20%）临床认为与之前的美容注射有关。可见多种填充物材料，包括胶原、羟磷灰石和硅胶，但以透明质酸基材料最为常见（50%，n=5）。 结论 美容用真皮填充剂的并发症越来越常见，对于不常见的口腔肿胀，应将其纳入鉴别诊断中。
