Master's Program in Stomatologic Medicine, Universidad Central de Venezuela, Caracas, Venezuela.
Department of Dentistry, University of Fortaleza, Fortaleza, Brazil.
Head Neck Pathol. 2023 Sep;17(3):631-637. doi: 10.1007/s12105-023-01563-9. Epub 2023 May 29.
Dermal facial fillers are increasingly popular. Published reports on the clinical and histopathologic characteristics related to adverse reactions to dermal fillers in the facial region have been relatively well documented. This study adds to the literature on adverse reactions to injected filler in the oral and maxillofacial region in a South American population.
A retrospective, descriptive cross-sectional study (2019-2020) was performed. The study population was a dermatology service in Venezuela. Clinical and histopathologic features of patients with adverse effects were documented.
A total of 35 cases of adverse reactions associated with cosmetic filler procedures were diagnosed during the analyzed period; of these, six cases (17.1%) involved the oral and maxillofacial region. All cases occurred in women. The mean age at diagnosis was 59.3 years (58-73). In three cases, dermal fillers were used in different locations on the face, while three involved the lips. Five patients exhibited adverse reactions to lip filler. All six cases were histopathologically diagnosed as foreign body reactions to injected material. Four and two cases revealed microscopic features compatible with hyaluronic acid and polymethylmethacrylate, respectively.
Reflecting the dramatic increase in cosmetic procedures with soft tissue fillers, this study contributed by reporting six cases of foreign body reaction involving the oral and maxillofacial region, confirmed with biopsy and histopathology.
真皮面部填充物越来越受欢迎。已发表的关于面部真皮填充物不良反应的临床和组织病理学特征的报告已得到充分记录。本研究增加了在南美洲人群中关于口腔和颌面区域注射填充物不良反应的文献。
回顾性描述性横断面研究（2019-2020 年）。研究人群为委内瑞拉的皮肤科服务。记录了有不良反应患者的临床和组织病理学特征。
在分析期间共诊断出 35 例与美容填充物程序相关的不良反应，其中 6 例（17.1%）涉及口腔和颌面区域。所有病例均发生在女性。诊断时的平均年龄为 59.3 岁（58-73）。在 3 例中，真皮填充物在面部的不同位置使用，而 3 例涉及嘴唇。5 名患者对唇部填充物出现不良反应。所有 6 例均经组织病理学诊断为注射材料的异物反应。4 例和 2 例分别显示出与透明质酸和聚甲基丙烯酸甲酯相容的微观特征。
反映出软组织填充物的美容手术急剧增加，本研究通过报告涉及口腔和颌面区域的 6 例异物反应病例，通过活检和组织病理学得到证实，对此做出了贡献。
