Department of Pediatric Dentistry, Shanghai Stomatological Hospital, Fudan University, Shanghai, China.
Oral Biomedical Engineering Laboratory, Shanghai Stomatological Hospital, Fudan University, Shanghai, China.
J Oral Pathol Med. 2020 Jan;49(1):96-99. doi: 10.1111/jop.12955. Epub 2019 Sep 5.
The correlation of ALDH1 and Bmi1 expression in potentially malignant oral erythroplakia (OE) with oral carcinoma development was reported in our earlier study. Interestingly, a model of field cancerization orchestrated by the cancer stem cells (CSC) was proposed and suggested the identification of CSC-specific markers is useful for prognosis and providing novel targets for prevention and treatment of field cancerization. We revisited the correlation of ALDH1 and Bmi1 expression in OE with the second and multiple carcinomas development. Strikingly, we observed that the expression of ALDH1 and Bmi1 within a single potentially malignant OE lesion significantly correlate with subsequently developing multiple and multifocal carcinomas, which parallels the process of oral field cancerization. Significantly, ALDH1 and Bmi1 are well-defined markers of CSC for head and neck cancer. Consequently, we provided a preliminary evidence for CSC driving the process of field cancerization.
我们之前的研究报告了潜在恶性口腔红斑病（OE）中 ALDH1 和 Bmi1 表达与口腔癌发展的相关性。有趣的是，提出了一个由癌症干细胞（CSC）协调的癌前病变的模型，并表明鉴定 CSC 特异性标志物对预后有用，并为癌前病变的预防和治疗提供了新的靶点。我们重新研究了 OE 中 ALDH1 和 Bmi1 的表达与第二和多个癌发展之间的相关性。引人注目的是，我们观察到单个潜在恶性 OE 病变中 ALDH1 和 Bmi1 的表达与随后发生的多个多灶性癌显著相关，这与口腔癌前病变的过程平行。重要的是，ALDH1 和 Bmi1 是头颈部癌症中 CSC 的明确标志物。因此，我们为 CSC 驱动癌前病变过程提供了初步证据。
