Yang Xi, Shi Linjun, Zhou Zengtong, Liu Wei
Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Oral Oncol. 2020 Feb;101:104368. doi: 10.1016/j.oraloncology.2019.07.011. Epub 2019 Jul 10.
A model of field cancerization orchestrated by the cancer stem cells (CSC) was proposed. Podoplanin and ABCG2 are promising marker of CSCs for head and neck cancer. We revisited the correlation of the two markers with the follow-up data of the patients with oral erythroplakia (OE). Strikingly, we observed that the expression of podoplanin and ABCG2 within a single pre-neoplastic OE lesion significantly correlate with subsequently developing multiple and multifocal carcinomas, thus to some extent demonstrating the concept of field cancerization. Collectively, a point to highlight was that a preliminary evidence that provided by this revisited study supported the perspective on cancer stem cells driving the process of field cancerization.
提出了一种由癌症干细胞（CSC）精心策划的场癌化模型。血小板反应蛋白-1和ABCG2是头颈癌CSC的有前景的标志物。我们重新审视了这两种标志物与口腔红斑（OE）患者随访数据的相关性。令人惊讶的是，我们观察到单个癌前OE病变内血小板反应蛋白-1和ABCG2的表达与随后发生的多发性和多灶性癌显著相关，从而在一定程度上证明了场癌化的概念。总的来说，一个需要强调的点是，这项重新审视的研究提供的初步证据支持了癌症干细胞驱动场癌化过程的观点。
