孕期母体免疫标志物与塞舌尔儿童发展研究中 20 月龄儿童神经发育结局的关系。
Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study.
机构信息
University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, United States of America.
Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Cromore Road, Coleraine, BT52 1SA Co. Londonderry, UK.
出版信息
J Neuroimmunol. 2019 Oct 15;335:577023. doi: 10.1016/j.jneuroim.2019.577023. Epub 2019 Aug 14.
Abstract
Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental outcomes. The direction of association for some markers was unexpected. Further research is warranted to confirm and elucidate the exact nature of these findings.
摘要
孕期免疫失调可能会影响后代的行为和神经发育，但很少有人类研究对此假设进行了检验。本研究采用结构方程模型，在 1453 对母婴样本中，分析了妊娠 28 周时母体炎症标志物与 20 个月时儿童神经发育结局之间的相关性。我们观察到在妊娠晚期或妊娠早期测量的几种母体炎症标志物与儿童神经发育结局之间存在相关性。一些标志物的关联方向出乎意料。需要进一步的研究来证实和阐明这些发现的确切性质。
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