年度研究综述：儿童应激与精神病理学的神经炎症假说——发育心理神经免疫学
Annual research review: The neuroinflammation hypothesis for stress and psychopathology in children--developmental psychoneuroimmunology.
作者信息
O'Connor Thomas G, Moynihan Jan A, Caserta Mary T
机构信息
University of Rochester Medical Center, Rochester, NY, USA.
出版信息
J Child Psychol Psychiatry. 2014 Jun;55(6):615-31. doi: 10.1111/jcpp.12187. Epub 2013 Dec 23.
Abstract
Experimental animal and adult human data suggest that stress exposure is associated with alterations in immune system function that may underlie increased susceptibility to disease and behavioral disorders. The implications of these data for child psychology and psychiatry are not yet clear. The current review seeks to distil and translate the relevant animal and adult human work to children to advance a developmental model of psychoneuroimmunology. In addition to reviewing key specific findings, we consider biological/conceptual models and technical aspects of psychoneuroimmunology work in pediatric populations, and outline the rationales and advantages of integrating hypotheses concerning neuroinflammation in developmental studies of psychopathology.
摘要
实验动物和成年人类的数据表明，暴露于压力之下与免疫系统功能的改变有关，而这可能是易患疾病和行为障碍增加的潜在原因。这些数据对儿童心理学和精神病学的影响尚不清楚。当前的综述旨在提炼与压力相关的动物和成年人类研究成果，并将其转化应用于儿童，以推进心理神经免疫学的发展模型。除了回顾关键的具体研究发现，我们还考虑了儿科人群心理神经免疫学研究的生物学/概念模型和技术方面，并概述了在精神病理学发展研究中整合神经炎症假说的基本原理和优势。
相似文献
1
Annual research review: The neuroinflammation hypothesis for stress and psychopathology in children--developmental psychoneuroimmunology.年度研究综述：儿童应激与精神病理学的神经炎症假说——发育心理神经免疫学
J Child Psychol Psychiatry. 2014 Jun;55(6):615-31. doi: 10.1111/jcpp.12187. Epub 2013 Dec 23.
2
Commentary: What does immunology have to do with brain development and psychopathology?--a commentary on O'Connor et al. (2014).评论：免疫学与大脑发育及精神病理学有何关系？——对奥康纳等人（2014年）的评论
J Child Psychol Psychiatry. 2014 Jun;55(6):632-4. doi: 10.1111/jcpp.12259.
3
Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?早期生活压力的心理神经免疫学：童年创伤的隐性创伤？
Neuropsychopharmacology. 2017 Jan;42(1):99-114. doi: 10.1038/npp.2016.198. Epub 2016 Sep 15.
4
Neuroinflammation: new vistas for neuropsychiatric research.神经炎症：神经精神疾病研究的新视野
Dialogues Clin Neurosci. 2017 Mar;19(1):3-4. doi: 10.31887/DCNS.2017.19.1/fthibaut.
5
Stress-induced immunomodulation and the implications for health.压力诱导的免疫调节及其对健康的影响。
Int Immunopharmacol. 2002 Feb;2(2-3):315-24. doi: 10.1016/s1567-5769(01)00182-5.
6
Psychoneuroimmunology and cancer: historical perspectives and current research.心理神经免疫学与癌症：历史视角与当前研究
Adv Neuroimmunol. 1996;6(2):179-90. doi: 10.1016/0960-5428(96)00016-2.
7
Psychoneuroimmunology. The interface between behavior, brain, and immunity.心理神经免疫学。行为、大脑与免疫之间的界面。
Am Psychol. 1994 Dec;49(12):1004-17. doi: 10.1037//0003-066x.49.12.1004.
8
Psychobiological responses to social threat: evolution of a psychological model in psychoneuroimmunology.对社会威胁的心理生物学反应：心理神经免疫学中心理模型的演变
Brain Behav Immun. 2009 Jan;23(1):1-9. doi: 10.1016/j.bbi.2008.08.008. Epub 2008 Sep 10.
9
Immunological research in clinical psychiatry: report on the consensus debate during the 7th Expert Meeting on Psychiatry and Immunology.临床精神病学中的免疫学研究：第七届精神病学与免疫学专家会议共识辩论报告
Mol Psychiatry. 2002;7(8):822-6. doi: 10.1038/sj.mp.4001115.
10
Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness.压力与神经炎症：压力对小胶质细胞影响及其对精神疾病影响的系统综述
Psychopharmacology (Berl). 2016 May;233(9):1637-50. doi: 10.1007/s00213-016-4218-9. Epub 2016 Feb 5.
引用本文的文献
1
Early life stress and iron metabolism in developmental psychoneuroimmunology.发育心理神经免疫学中的早期生活应激与铁代谢
Brain Behav Immun Health. 2024 Jul 16;40:100824. doi: 10.1016/j.bbih.2024.100824. eCollection 2024 Oct.
2
Dangers of the chronic stress response in the context of the microbiota-gut-immune-brain axis and mental health: a narrative review.慢性应激反应在微生物群-肠道-免疫-脑轴与心理健康方面的危险：一篇叙述性综述。
Front Immunol. 2024 May 2;15:1365871. doi: 10.3389/fimmu.2024.1365871. eCollection 2024.
3
Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children.不同队列中早龄儿童的童年不良经历与炎症生物标志物
Brain Behav Immun Health. 2019 Nov 14;1:100006. doi: 10.1016/j.bbih.2019.100006. eCollection 2020 Jan.
4
Blood-derived deoxyribonucleic acid methylation clusters associate with adverse social exposures and endophenotypes of stress-related psychiatric illness in a trauma-exposed cohort of women.在一个遭受创伤的女性队列中，血液来源的脱氧核糖核酸甲基化簇与不良社会暴露以及应激相关精神疾病的内表型相关。
Front Psychiatry. 2022 Nov 3;13:892302. doi: 10.3389/fpsyt.2022.892302. eCollection 2022.
5
Clenbuterol attenuates immune reaction to lipopolysaccharide and its relationship to anhedonia in adolescents.克仑特罗减轻青少年对脂多糖的免疫反应及其与快感缺失的关系。
Brain Behav Immun. 2022 Nov;106:89-99. doi: 10.1016/j.bbi.2022.07.163. Epub 2022 Jul 29.
6
Maternal prenatal infection and anxiety predict neurodevelopmental outcomes in middle childhood.母体产前感染和焦虑可预测儿童中期的神经发育结局。
J Psychopathol Clin Sci. 2022 May;131(4):422-434. doi: 10.1037/abn0000746. Epub 2022 Mar 3.
7
Maternal Immune Activation Hypotheses for Human Neurodevelopment: Some Outstanding Questions.母体免疫激活假说对人类神经发育的影响：一些悬而未决的问题。
Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 May;7(5):471-479. doi: 10.1016/j.bpsc.2021.10.006. Epub 2021 Oct 21.
8
Do Anxiety and Depression Levels Affect the Inflammation Response in Patients Hospitalized for COVID-19.焦虑和抑郁水平会影响因新冠肺炎住院患者的炎症反应吗？
Psychiatry Investig. 2021 Jun;18(6):505-512. doi: 10.30773/pi.2021.0029. Epub 2021 Jun 17.
9
Moving the dial on prenatal stress mechanisms of neurodevelopmental vulnerability to mental health problems: A personalized prevention proof of concept.推动产前应激机制向精神健康问题的神经发育脆弱性转变：个性化预防概念验证。
Dev Psychobiol. 2021 May;63(4):622-640. doi: 10.1002/dev.22057. Epub 2020 Nov 22.
10
Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders.小胶质细胞对神经元的吞噬作用：减少创伤性、感染性、炎症性和自身免疫性中枢神经系统疾病中的神经元损失
Front Psychiatry. 2019 Oct 3;10:712. doi: 10.3389/fpsyt.2019.00712. eCollection 2019.
本文引用的文献
1
Research review: the role of cytokines in depression in adolescents: a systematic review.研究综述：细胞因子在青少年抑郁症中的作用：系统综述。
J Child Psychol Psychiatry. 2013 Aug;54(8):816-35. doi: 10.1111/jcpp.12080.
2
The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders.母体产前和儿童早期营养以及母体产前应激对后代免疫系统发育和神经发育障碍的影响。
Front Neurosci. 2013 Jul 31;7:120. doi: 10.3389/fnins.2013.00120. eCollection 2013.
3
Epigenetic regulation of inducible gene expression in the immune system.免疫系统中诱导基因表达的表观遗传调控。
Immunology. 2013 Jul;139(3):285-93. doi: 10.1111/imm.12100.
4
Frank A. Beach award: programming of neuroendocrine function by early-life experience: a critical role for the immune system.弗兰克 A. 比奇奖：早期生活经历对神经内分泌功能的编程作用：免疫系统的关键作用。
Horm Behav. 2013 May;63(5):684-91. doi: 10.1016/j.yhbeh.2013.02.017. Epub 2013 Mar 6.
5
Microglia regulate the number of neural precursor cells in the developing cerebral cortex.小胶质细胞调节发育中的大脑皮层中的神经前体细胞的数量。
J Neurosci. 2013 Mar 6;33(10):4216-33. doi: 10.1523/JNEUROSCI.3441-12.2013.
6
Prenatal maternal anxiety predicts reduced adaptive immunity in infants.产前孕妇焦虑可预测婴儿适应性免疫降低。
Brain Behav Immun. 2013 Aug;32:21-8. doi: 10.1016/j.bbi.2013.02.002. Epub 2013 Feb 21.
7
Prenatal maternal mood is associated with altered diurnal cortisol in adolescence.产前母亲的情绪与青春期日间皮质醇变化有关。
Psychoneuroendocrinology. 2013 Sep;38(9):1630-8. doi: 10.1016/j.psyneuen.2013.01.008. Epub 2013 Feb 22.
8
Microglial activation in young adults with autism spectrum disorder.自闭症谱系障碍青年的小胶质细胞激活。
JAMA Psychiatry. 2013 Jan;70(1):49-58. doi: 10.1001/jamapsychiatry.2013.272.
9
Adverse childhood experiences: translating knowledge into identification of children at risk for poor outcomes.不良童年经历：将知识转化为识别可能导致不良后果的儿童。
Acad Pediatr. 2013 Jan-Feb;13(1):14-9. doi: 10.1016/j.acap.2012.10.006.
10
Psychoneuroendocrine interventions aimed at attenuating immunosenescence: a review.旨在减轻免疫衰老的心理神经内分泌干预措施：综述。
Biogerontology. 2013 Feb;14(1):9-20. doi: 10.1007/s10522-012-9412-5. Epub 2013 Jan 3.
Zotero 插件