Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.
Pathology. 2019 Oct;51(6):600-604. doi: 10.1016/j.pathol.2019.04.009. Epub 2019 Aug 21.
Oncocytic metaplastic lesions of the nasopharynx are rare benign entities which are divided into melanotic and non-melanotic forms. Less than 40 non-melanotic and 30 melanotic cases have been reported in the literature. We present the largest known case series to date of melanotic oncocytic metaplasia and more than 20 cases of non-melanotic oncocytic metaplasia. Clinical, endoscopic, histological and immunohistochemical features were reviewed. Most cases presented in males starting from their late adulthood. Compared to its non-melanotic counterpart, all cases of melanotic oncocytic metaplasia had a smoking history (p=0.041). All cases of melanotic oncocytic metaplasia were negative to melanocytic markers (S100, HMB-45, Melan-A and MiTF). Although no disease-related mortality was recorded, concurrent melanoma and nasopharyngeal carcinoma were seen in two cases.
鼻咽部的嗜酸细胞化生性肿瘤是罕见的良性病变，可分为黑色素型和非黑色素型。文献报道的非黑色素型不到 40 例，黑色素型不到 30 例。我们报告了迄今为止最大的已知黑色素嗜酸细胞化生病例系列，以及 20 多例非黑色素嗜酸细胞化生病例。对临床、内镜、组织学和免疫组织化学特征进行了回顾。大多数病例发生在男性，始于成年后期。与非黑色素型相比，所有黑色素嗜酸细胞化生病例均有吸烟史（p=0.041）。所有黑色素嗜酸细胞化生病例均对黑色素细胞标志物（S100、HMB-45、Melan-A 和 MiTF）呈阴性。虽然没有记录到与疾病相关的死亡率，但在 2 例中同时发现了黑色素瘤和鼻咽癌。
