Olszewer E, Carter J P
Hyperbaric Oxygen Clinic, Sao Paulo, Brazil.
Med Hypotheses. 1988 Sep;27(1):41-9. doi: 10.1016/0306-9877(88)90082-5.
A retrospective analysis of treatment results from 2870 patients, with various chronic degenerative and age-associated diseases, who were treated with di-sodium magnesium EDTA chelation therapy, suggests that the case against EDTA Chelation Therapy should be re-opened. Using qualitative but never-the-less standardized criteria for improvement, our analysis shows that EDTA Chelation Therapy resulted in "marked" improvement in 76.89% and "good" improvement in 16.56% of patients with ischemic heart disease; also, "marked" improvement in 91% and "good" improvement in 7.6% of patients with peripheral vascular disease and intermittent claudication. In a group of patients with cerebro-vascular and other degenerative cerebral diseases, 24% had "marked" improvement, and 30% had "good" improvement. Of four patients with scleroderma, three had "marked" improvement and one had "good" improvement. Seventy-five percent of all of the patients had "marked" improvement in "geriatric symptomatology of vascular origin". The authors recommend renewed study of EDTA Chelation Therapy. The possibility of a "tomato effect", i.e., a drug which works, but the majority of physicians believe that it doesn't work, needs to be ruled out. A favorable climate needs to be created, in which FDA-approved studies of its usefulness in treating peripheral vascular disease can take place.
对2870例患有各种慢性退行性疾病和与年龄相关疾病的患者进行乙二胺四乙酸二钠螯合疗法治疗结果的回顾性分析表明,应重新审视对乙二胺四乙酸螯合疗法的质疑。我们的分析采用定性但标准化的改善标准,结果显示,乙二胺四乙酸螯合疗法使76.89%的缺血性心脏病患者得到“显著”改善,16.56%的患者得到“良好”改善;对于外周血管疾病和间歇性跛行患者,91%的患者得到“显著”改善,7.6%的患者得到“良好”改善。在一组脑血管及其他退行性脑部疾病患者中,24%的患者得到“显著”改善,30%的患者得到“良好”改善。4例硬皮病患者中,3例得到“显著”改善,1例得到“良好”改善。所有患者中有75%在“血管源性老年症状”方面得到“显著”改善。作者建议重新研究乙二胺四乙酸螯合疗法。需要排除“番茄效应”的可能性,即一种药物有效,但大多数医生认为它无效。需要营造一个有利的环境,以便美国食品药品监督管理局批准开展关于其治疗外周血管疾病有效性的研究。