Sparchez Zeno, Mocan Tudor, Hagiu Claudia, Kacso Gabriel, Zaharie Toader, Rusu Ioana, Al Hajjar Nadim, Leucuta Daniel Corneliu, Sparchez Mihaela
3rd Medical Department, Institute for Gastroenterology and Hepatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
3rd Medical Department, Institute for Gastroenterology and Hepatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Ultrasound Med Biol. 2019 Nov;45(11):2915-2924. doi: 10.1016/j.ultrasmedbio.2019.07.678. Epub 2019 Aug 22.
We aimed to compare contrast-enhanced-guided liver biopsy (CEUSLB) and ultrasound-guided liver biopsy (USLB) in the diagnosis of focal liver lesions (FLLs) developed on a background of advanced chronic liver disease (ACLD). Between 2011 and 2019, patients diagnosed with liver tumors on a background of ACLD were evaluated for inclusion in the study. Patients were randomly assigned to the CEUSLB or USLB group. In total, 144 patients were randomly assigned to either CEUSLB (n = 79) or USLB (n = 65). Overall, in the CEUSLB group, the sensitivity was significantly better (94.74% vs. 74.6%, respectively; p = 0.001). Both the fragment length of the biopsy specimen and the single puncture success rate were statistically higher in the CEUSLB group (p = 0.022 and p = 0.0006, respectively). There was no difference in terms of major or minor complications (p = 0.682). CEUSLB is a feasible technique that increases the diagnostic sensitivity for liver tumors developed in ACLD.
我们旨在比较对比增强引导下肝活检（CEUSLB）和超声引导下肝活检（USLB）在诊断晚期慢性肝病（ACLD）背景下发生的局灶性肝病变（FLL）中的应用。在2011年至2019年期间，对诊断为ACLD背景下肝肿瘤的患者进行评估以纳入本研究。患者被随机分配到CEUSLB组或USLB组。总共144例患者被随机分配到CEUSLB组（n = 79）或USLB组（n = 65）。总体而言，在CEUSLB组中，敏感性明显更高（分别为94.74%和74.6%；p = 0.001）。CEUSLB组活检标本的碎片长度和单次穿刺成功率在统计学上均更高（分别为p = 0.022和p = 0.0006）。在主要或次要并发症方面没有差异（p = 0.682）。CEUSLB是一种可行的技术，可提高ACLD中发生的肝肿瘤的诊断敏感性。
