Liu Ming, Liu Yingxin, Zhou Wenying, Pan Fushun, Chen Meixi, Xie Xiaoyan, Zhou Luyao
Department of Medical Ultrasonics, Institute for Diagnostic and Interventional Ultrasound, The First Affiliated Hospital, Sun Yat-Sen University, No 58, Zhongshan Er Road, 510080, Guangzhou, P.R. China.
Department of Ultrasound, Shenzhen Children' Hospital, No. 7019, Yitian Road, Futian District, 518026, Shenzhen, P.R. China.
Eur Radiol. 2025 Feb;35(2):1001-1011. doi: 10.1007/s00330-024-11018-6. Epub 2024 Aug 14.
To compare the diagnostic performance of CEUS-guided biopsy (CEUS-GB) and ultrasound-guided biopsy (US-GB) in evaluating abdominal and pelvic (abdominopelvic) neoplasms in paediatric patients.
Patients aged < 18 years with abdominopelvic tumours who underwent either CEUS-GB or US-GB between April 2005 and May 2022 were retrospectively evaluated. Tumours diagnosed as malignancies by pathology were considered true-positive findings. Benign lesions were identified by pathology or clinical follow-up of at least 6 months. The diagnostic performance of the two groups was compared using propensity score matching (PSM). Complications were also analysed.
The present study included 764 paediatric patients (437 boys; median age, 24 months; interquartile range, 10-60 months); 151 were in the CEUS-GB group, and 613 were in the US-GB group. The sample adequacy rate was 100% (151 of 151) for the CEUS-GB group, which was greater than the 97.4% (597 of 613) for the US-GB group (p < 0.001). The overall diagnostic accuracy of the CEUS-GB group and US-GB group was 98.7% (149 of 151) versus 97.3% (581 of 597) in the total cohort (p = 0.551) and 98.7% (149 of 151) versus 92.7% (140 of 151) in the PSM cohort (p = 0.020). Two patients (0.3%) in the US-GB group experienced complications (Common Terminology Criteria for Adverse Events (CTCAE), grade 1-2) correlated with the biopsy. No adverse reactions occurred in the CEUS-GB group.
CEUS-GB of abdominopelvic tumours in paediatric patients is an effective and safe procedure with greater diagnostic accuracy than US-GB, especially for tumours with necrotic areas.
Contrast-enhanced US-guided biopsy of solid abdominal and pelvic tumours in paediatric patients is an effective and safe procedure with greater diagnostic accuracy than US-guided biopsy, especially for tumours with necrotic areas.
Contrast-enhanced ultrasound (CEUS) may be superior to conventional ultrasound at guiding biopsy of abdominopelvic masses in paediatric patients. CEUS-guided core needle biopsy of abdominopelvic masses in children was safe and resulted in a diagnostic yield of 98.7%. CEUS guidance should be considered in this population when colour Doppler US is unable to determine a biopsy site.
比较超声造影引导下活检（CEUS-GB）与超声引导下活检（US-GB）在评估儿科患者腹部和盆腔（腹盆腔）肿瘤中的诊断性能。
回顾性评估2005年4月至2022年5月期间接受CEUS-GB或US-GB的18岁以下腹盆腔肿瘤患者。经病理诊断为恶性肿瘤的被视为真阳性结果。良性病变通过病理或至少6个月的临床随访确定。使用倾向评分匹配（PSM）比较两组的诊断性能。还分析了并发症。
本研究纳入764例儿科患者（437例男孩；中位年龄24个月；四分位间距10 - 60个月）；CEUS-GB组151例，US-GB组613例。CEUS-GB组样本充足率为100%（151例中的151例），高于US-GB组的97.4%（613例中的597例）（p < 0.001）。在整个队列中，CEUS-GB组和US-GB组的总体诊断准确率分别为98.7%（151例中的149例）和97.3%（597例中的581例）（p = 0.551），在PSM队列中分别为98.7%（151例中的149例）和92.7%（151例中的140例）（p = 0.020）。US-GB组有2例患者（0.3%）发生与活检相关的并发症（不良事件通用术语标准（CTCAE），1 - 2级）。CEUS-GB组未发生不良反应。
儿科患者腹盆腔肿瘤的CEUS-GB是一种有效且安全的操作，诊断准确性高于US-GB，并尤其适用于有坏死区域的肿瘤。
儿科患者腹部和盆腔实体肿瘤的超声造影引导下活检是一种有效且安全的操作，诊断准确性高于超声引导下活检，尤其适用于有坏死区域的肿瘤。
超声造影（CEUS）在引导儿科患者腹盆腔肿块活检方面可能优于传统超声。儿童腹盆腔肿块的CEUS引导下粗针活检安全，诊断率为98.7%。当彩色多普勒超声无法确定活检部位时，该人群应考虑采用CEUS引导。
