Wang Bo, Liu Fang, Zhang Er Chun, Wo Chen Liang, Chen Jason, Qian Pu Yi, Lu Hao Rong, Zeng Wen Jun, Chen Tai, Wei Jin Pu, Wan Qian, Wang Ren, Xu Xun
China National GeneBank, Shenzhen 518120 ,China.
BGI-Shenzhen, Shenzhen 518083, China.
Yi Chuan. 2019 Aug 20;41(8):761-772. doi: 10.16288/j.yczz.19-148.
Genetic resources are important national strategic resources. Their preservation, protection and rational utilization form a solid foundation to guarantee national security and to build national competitiveness for the future. Due to a relatively late starting point, China is actively catching up with global peers in storing genetic samples and data. In view of this, in 2011 China approved a plan to build its first nation-level comprehensive gene bank, the China National GeneBank (CNGB), and entrusted BGI-Research to implement its construction and operation. It is China's first gene bank for "reading, writing and storing" bioresources. In this paper, we summarize the development of influential platforms at home and abroad, and focus on CNGB's position, mission, and its structure of "Three Banks and Two Platforms". CNGB launched its official operation in September 2016 and aims to develop a world-class, non-profit and strategic platform that supports science and technology development. It has built capacities to store tens of millions of traceable samples and to analyze handreds of thousanda of WGS each year. It has also set up China's first Pb-level digitalization platform and a high-efficient synthesis platform with a production rate of ten million bases per year. Based on such capacities, CNGB has established its open sharing mechanism for biological samples and data, provided public platform services for life science research, and achieved initial results in supporting innovation and development of the bio-industry.
遗传资源是重要的国家战略资源。其保存、保护和合理利用是保障国家安全、打造未来国家竞争力的坚实基础。由于起步相对较晚，中国在存储遗传样本和数据方面正积极追赶全球同行。鉴于此，2011年中国批准了建设首个国家级综合性基因库——中国国家基因库（CNGB）的计划，并委托华大研究院进行建设和运营。它是中国首个具备“读、写、存”生物资源能力的基因库。在本文中，我们总结了国内外有影响力的平台的发展情况，并重点介绍了中国国家基因库的定位、使命及其“三库两平台”架构。中国国家基因库于2016年9月正式运营，旨在打造一个支持科技发展的世界级、非营利性战略平台。它已具备存储数千万份可溯源样本以及每年分析数十万例全基因组测序的能力。它还搭建了中国首个拍字节级别的数字化平台以及一个年产能达千万碱基的高效合成平台。基于这些能力，中国国家基因库建立了生物样本和数据的开放共享机制，为生命科学研究提供公共平台服务，并在支持生物产业创新发展方面取得了初步成效。
