Jain Shreshtha, Khanduri Sachin, Khan Mazhar, Khan Shahla, Yadav Vivek K, Khan Basmah R, Sagar Umar Faizan, Rajurkar Mridul
Department of Radiodiagnosis, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.
J Clin Imaging Sci. 2019 May 24;9:14. doi: 10.25259/JCIS-15-2019. eCollection 2019.
Our objective for this study was to establish a reference range of normal fetal nasal bone length (NBL) from 14 to 22 weeks in a North Indian population.
Pregnant women with gestational age (GA) from 14 to 22 weeks undergoing ultrasonography with a single live fetus and no complications in the fetus or mother were selected for the study. The fetal nasal bone was measured in 2060 pregnant women from 2014 to 2018. The measurement was done by the double operator method; three measurements were taken for each woman when her fetus was in the midsagittal plane, and the nasal bone was located between a 45 and 135° angle to the ultrasound beam. We performed follow-up evaluations of all neonates.
The rate of growth of the fetal nasal bone during different weeks of gestation is described by an equation where NBL =0.365×GA+ 2.5885, with a fit estimate of R = 0.97, < 0.001. The median NBL increased with GA from 2.9 mm at 14 weeks to 5.8 mm at 22 weeks in a linear relationship. Our results in the North Indian population are similar to those in the South Indian population and differ from those in Chinese and Japanese populations.
The NBL in North Indian fetuses at 14-26 weeks of GA has a linear relationship to the week of gestation.
本研究的目的是建立北印度人群中孕14至22周正常胎儿鼻骨长度（NBL）的参考范围。
选择孕周为14至22周、单活胎且胎儿或母亲无并发症的孕妇进行超声检查，纳入本研究。对2014年至2018年期间的2060名孕妇的胎儿鼻骨进行测量。测量采用双操作者法；当胎儿处于正中矢状面且鼻骨与超声束夹角在45至135°之间时，对每位孕妇进行三次测量。我们对所有新生儿进行了随访评估。
胎儿鼻骨在不同孕周的生长速率由方程NBL =0.365×GA + 2.5885描述，拟合估计R = 0.97，P < 0.001。中位数NBL随孕周增加，从14周时的2.9毫米线性增加至22周时的5.8毫米。我们在北印度人群中的结果与南印度人群相似，与中国和日本人群不同。
孕14至26周的北印度胎儿NBL与孕周呈线性关系。
