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在C-3位直接获得取代的4-CFβ-内酰胺。

Direct Access to Substituted 4-CF β-Lactams at the C-3 Position.

作者信息

Skibińska Monika, Kaźmierczak Marcin, Milcent Thierry, Cytlak Tomasz, Koroniak Henryk, Crousse Benoit

机构信息

Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland.

Faculté de Pharmacie, UMR 8076 CNRS, BioCIS, University of Paris-Sud, Univ. Paris-Saclay, Châtenay-Malabry, France.

出版信息

Front Chem. 2019 Aug 6;7:526. doi: 10.3389/fchem.2019.00526. eCollection 2019.

DOI:10.3389/fchem.2019.00526
PMID:31448256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6691124/
Abstract

Mono- and disubstituted 4-CF β-lactams at the C-3 position have been obtained stereoselectively under basic conditions. A wide range of function such as alcohols, alkyls, aryls, esters, and double and triple bonds have been introduced.

摘要

在碱性条件下已立体选择性地获得了C-3位单取代和双取代的4-CFβ-内酰胺。已引入了多种官能团，如醇、烷基、芳基、酯以及双键和三键。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/ae38246ae423/fchem-07-00526-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/c193bc0de92d/fchem-07-00526-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/75bf96420ae6/fchem-07-00526-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/063236d89752/fchem-07-00526-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/741f6ba7c5e5/fchem-07-00526-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/935164d49ad0/fchem-07-00526-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/d8ce09c1f7be/fchem-07-00526-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/bfee2fdef88b/fchem-07-00526-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/ae38246ae423/fchem-07-00526-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/c193bc0de92d/fchem-07-00526-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/75bf96420ae6/fchem-07-00526-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/063236d89752/fchem-07-00526-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/741f6ba7c5e5/fchem-07-00526-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/935164d49ad0/fchem-07-00526-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/d8ce09c1f7be/fchem-07-00526-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/bfee2fdef88b/fchem-07-00526-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a040/6691124/ae38246ae423/fchem-07-00526-g0007.jpg

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